{"created":"2023-06-19T11:43:40.495924+00:00","id":13307,"links":{},"metadata":{"_buckets":{"deposit":"77333969-6a02-4137-b994-9e649fa9ec05"},"_deposit":{"created_by":15,"id":"13307","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13307"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013307","sets":["420:724:1692755176241"]},"author_link":["43418","43419"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨細胞にメカニカルストレスを負荷することで分泌されたエクソソームを骨芽細胞および破骨細胞にそれぞれ添加し，骨形成および骨吸収への影響を検討した。メカニカルストレス処理骨細胞由来のエクソソームの添加は骨芽細胞の分化を誘導せず，破骨細胞様細胞への分化を誘導した。また，メカニカルストレス処理の骨細胞から放出されるエクソソームには，破骨細胞の分化で機能する分子を標的とするmiRNAが多く包含されていた。以上のことから，メカニカルストレスを受けた骨細胞から放出されるエクソソームは，破骨細胞の分化を骨形成よりも優先的にすることが分った。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we demonstrated the effect of exosome (MS-Ov) released from mechanical stress-stimulated osteocyte on osteogenesis or osteoclastogenesis. The MS-Ov treatment induced osteoclast formation, but had no change in osteoblast differentiation. Moreover, MS-Ov contained miRNAs targeting osteoclastogenesis-related molecules. From these results, it was found that MS-Ov gives more priority to osteoclastogenesis than to osteogenesis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K12714","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 智広","creatorNameLang":"ja"},{"creatorName":"イトウ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"ITOH, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤尾, 幸博","creatorNameLang":"ja"},{"creatorName":"アカオ, ユキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"AKAO, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43419","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0092.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0092","url":"https://mie-u.repo.nii.ac.jp/record/13307/files/2019RP0092.pdf"},"version_id":"2823f1aa-2060-4a08-8c96-893d0a51842a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エクソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"分化","subitem_subject_scheme":"Other"},{"subitem_subject":"メカニカルストレス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨形成関連ｍｉｃｒｏＲＮＡを包含したｅｘｏｓｏｍｅの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨形成関連ｍｉｃｒｏＲＮＡを包含したｅｘｏｓｏｍｅの開発","subitem_title_language":"ja"},{"subitem_title":"Development of exosome including osteogenesis-related microRNA","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692755176241"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13307","relation_version_is_last":true,"title":["骨形成関連ｍｉｃｒｏＲＮＡを包含したｅｘｏｓｏｍｅの開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T00:57:08.169654+00:00"}