{"created":"2023-06-19T11:43:40.749438+00:00","id":13313,"links":{},"metadata":{"_buckets":{"deposit":"4488dee6-6e47-455e-b29f-c19a14027cbb"},"_deposit":{"created_by":15,"id":"13313","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13313"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013313","sets":["515:756:1692664532953"]},"author_link":["43472"],"control_number":"13313","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-23","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肥満は2型糖尿病の発症を増加させる最も重要な因子と考えられている。肥満によるインスリン抵抗性発症メカニズムを明らかにすることは、2型糖尿病およびその合併症の予防と治療において最大の研究テーマである。私たちは、2型糖尿病モデルゼブラフィッシュを用いて、幾つかの治療標的遺伝子候補を発見してきた。本研究では、米国ヴァンダービルト大学医学部のWenbiao Chen教授と国際共同研究を通して、これまで発見してきた新規治療標的遺伝子のバリデーションスタディを行った。その結果、耐糖能異常に関与する２つの新規治療標的遺伝子を発見した。","subitem_description_type":"Abstract"},{"subitem_description":"Obesity is considered as one of the most important factors that facilitates the incidents of type 2 diabetes mellitus (T2DM). The onset mechanism of insulin resistance induced by obesity is the greatest research interest in the prevention and treatment of T2DM with its complications. We have found several candidates of therapeutic target genes by using our original zebrafish model for T2DM. In this study, we performed validation studies of these candidates by international collaborating with Prof. Wenbiao Chen in Vanderbilt University School of Medicine, USA. As a result, we discovered two novel therapeutic targets involved in glucose intolerance.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2017年度科学研究費補助金(国際共同研究加速基金(国際共同研究強化))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15KK0305","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臧, 黎清","creatorNameLang":"ja"},{"creatorName":"ゾウ, レイシン","creatorNameLang":"ja-Kana"},{"creatorName":"Zang, Liqing","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0102.pdf","filesize":[{"value":"560.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0102","url":"https://mie-u.repo.nii.ac.jp/record/13313/files/2019RP0102.pdf"},"version_id":"2af90e88-e59a-4937-8a0d-6590785848c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼブラフィッシュ","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子抑制","subitem_subject_scheme":"Other"},{"subitem_subject":"治療標的遺伝子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索（国際共同研究強化）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索（国際共同研究強化）","subitem_title_language":"ja"},{"subitem_title":"Identification of therapeutic target genes and early diagnosis biomarkers of abnormal glucose tolerance using a zebrafish model(Fostering Joint International Research)","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692664532953"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13313","relation_version_is_last":true,"title":["耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索（国際共同研究強化）"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T05:06:08.762289+00:00"}