{"created":"2023-06-19T11:43:40.834162+00:00","id":13315,"links":{},"metadata":{"_buckets":{"deposit":"5d0cdbd7-0399-45e2-82c9-69c331bf19c7"},"_deposit":{"created_by":15,"id":"13315","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13315"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013315","sets":["515:756:1692664532953"]},"author_link":["43481","43482","43483"],"control_number":"13315","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"①1960年代以降、グアム島＞紀伊半島の順に、特に ALS が減少している。②紀伊患者脳内においてソテツや藍藻由来の神経毒(BMAA)に有意な蓄積はみられなかった。③ゲノムワイド関連解析を行い、5染色体において、ゲノムワイドにsuggestiveとされる、p<10-5となるSNPを認めた。C9orf72遺伝子以外のGGGGCC異常伸張についてリピートの伸張は認めなかった。④日本神経学会監修による、紀伊ALS/PDC の臨床診断基準と重症度分類を策定、公表した。⑤神経毒 BMAA、小脳病理、OPTN病理、ニトロ化ストレス、に関する論文が国際誌に採択された。","subitem_description_type":"Abstract"},{"subitem_description":"①After 1960’, ALS/PDC, especially ALS, has been decreasing in the Kii peninsula subsequently to on Guam island.②No or only subtle accumulation of BMAA (β-Methylamino-L-alanine) in the brains of Kii patients.③GWAS revealed candidate SNPs of 5 chromosomes in the patients with Kii ALS/PDC. The diagnostic criteria and severity index were published under supervision by the Japanese Society of Neurology. ④New articles regarding neurotoxic BMAA, cerebellar neuropathology, OPTN neuropathology and nitration stress have been accepted by several international journals.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2017年度科学研究費補助金(基盤研究(B)(海外学術調査))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25305030","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小久保, 康昌","creatorNameLang":"ja"},{"creatorName":"コクボ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"KOKUBO, Yasumasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"葛原, 茂樹","creatorNameLang":"ja"},{"creatorName":"クズハラ, シゲキ","creatorNameLang":"ja-Kana"},{"creatorName":"KUZUHARA, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 省次","creatorNameLang":"ja"},{"creatorName":"ツジ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TSUJI, Syouji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43483","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0105.pdf","filesize":[{"value":"277.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0105","url":"https://mie-u.repo.nii.ac.jp/record/13315/files/2019RP0105.pdf"},"version_id":"18146429-efa1-4a19-9214-95b7317517ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋萎縮性側索硬化症","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン認知症複合","subitem_subject_scheme":"Other"},{"subitem_subject":"紀伊半島","subitem_subject_scheme":"Other"},{"subitem_subject":"グアム島","subitem_subject_scheme":"Other"},{"subitem_subject":"神経変性疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"難病","subitem_subject_scheme":"Other"},{"subitem_subject":"認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン症候群","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"紀伊半島とグアム島のALS/PDC　-共通する環境と遺伝素因の探索-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"紀伊半島とグアム島のALS/PDC　-共通する環境と遺伝素因の探索-","subitem_title_language":"ja"},{"subitem_title":"Common environmental and genetic factors of ALS/PDC between Kii and Guam","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692664532953"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13315","relation_version_is_last":true,"title":["紀伊半島とグアム島のALS/PDC　-共通する環境と遺伝素因の探索-"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T05:19:52.512097+00:00"}