{"created":"2023-06-19T11:43:40.920251+00:00","id":13317,"links":{},"metadata":{"_buckets":{"deposit":"d4f2274f-633f-416b-886f-a6fdd57b2c40"},"_deposit":{"created_by":15,"id":"13317","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13317"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013317","sets":["758:761:1692665904132"]},"author_link":["43496","43497"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Parkinの基質として同定された転写因子PARISがSUMO化されることを発見し、その機能とパーキンソン病発症へのSUMO化の関与を解析した。その結果、PARISのSUMO化依存的な転写活性調節を明らかにした。さらにPARISのSUMO化はそのユビキチン化も制御していることを明らかにした。さらにPARISのSUMO化を制御する因子を同定し、それらがPARISの転写活性やユビキチン化に与える影響を明らかにした。本研究の成果はパーキンソン病発症メカニズムにおけるSUMO化の重要性を示唆した。","subitem_description_type":"Abstract"},{"subitem_description":"PARIS is identified as a substrate of the ubiquitin ligase, parkin, a gene associated with Parkinson's disease. PARIS represses the expression of the transcriptional co-activator PGC-1α, although the mechanism that controls its repressive activity and function are largely unknown. We have shown that PARIS can be modified by SUMO and that SUMOylation of PARIS regulates its transcriptional activity. We have also shown that SUMOylation of PARIS also controls its ubiquitination. The proteasome inhibitor treatment accumulated SUMO-2/3 conjugates of PARIS. The SUMOylated PARIS was more effectively ubiquitinated than the non-SUMOylated form of PARIS. The SUMO-targeted ubiquitin ligase RNF4 promoted the ubiquitination of SUMOylated PARIS. These results suggest that RNF4-mediated ubiquitination of PARIS regulates its transcription function. We believe the present study results may improve our understanding of the role of SUMOylation in neurodegeneration in Parkinson's disease.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K06738","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西田, 有","creatorNameLang":"ja"},{"creatorName":"ニシダ, タモツ","creatorNameLang":"ja-Kana"},{"creatorName":"NISHIDA, Tamotsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"榊原, 伸一","creatorNameLang":"ja"},{"creatorName":"サカキバラ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"SAKAKIBARA, Shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"43497","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0107.pdf","filesize":[{"value":"185.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0107","url":"https://mie-u.repo.nii.ac.jp/record/13317/files/2019RP0107.pdf"},"version_id":"4c89d4bb-d8ae-4ae9-bca4-60ede6dac41d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"タンパク質翻訳後修飾","subitem_subject_scheme":"Other"},{"subitem_subject":"ＳＵＭＯ化","subitem_subject_scheme":"Other"},{"subitem_subject":"ユビキチン化","subitem_subject_scheme":"Other"},{"subitem_subject":"神経変性疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン病","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経変性疾患に関与する転写因子のＳＵＭＯ化による機能変換の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経変性疾患に関与する転写因子のＳＵＭＯ化による機能変換の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of functional exchange of the transcriptional factors involved in neurodegenerative diseases by SUMO modification.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692665904132"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13317","relation_version_is_last":true,"title":["神経変性疾患に関与する転写因子のＳＵＭＯ化による機能変換の解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-22T05:12:27.219143+00:00"}