{"created":"2023-06-19T11:43:47.062994+00:00","id":13460,"links":{},"metadata":{"_buckets":{"deposit":"77124847-b2aa-4582-af9b-9df82dc47e51"},"_deposit":{"created_by":16,"id":"13460","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"13460"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013460","sets":["334:608:618:1214"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: We investigated the effect of carbonic anhydrase IX (CA IX) inhibitor under hypoxia and normoxia in SaOS2 human osteosarcoma cell line. We also evaluated the expres- sion of CA IX in 27 patients diagnosed with osteosarcoma.\nMaterials and methods: CA IX expression in SaOS2 cells cultured under different oxygen tensions was analyzed by Western blotting. To evaluate the effect of CA IX inhibitor, MTS cell viability assay was performed after cells were treated with various concentrations of doxorubicin with or without a CA IX inhibitor. Finally, CA IX expression in patient-derived osteosarcoma samples was evaluated by immunohistochemistry.\nResults: Treatment with CA IX inhibitor significantly suppressed cell proliferation and migration under hypoxic conditions. CA IX expression was observed in 81% of 27 patients. The 5-year survival rates in patients with high and low stain scores were 43.8% and 81.8%, respectively.\nConclusion: CA IX inhibitors have the potential to suppress cell proliferation, migration, and chemoresistance.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan","subitem_description_type":"Other"},{"subitem_description":"8p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第1049号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/OTT.S177605","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"OncoTargets and Therapy 2018:11 6879–6886に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okuno, Kazuma","creatorNameLang":"en"},{"creatorName":"オクノ, カズマ","creatorNameLang":"ja-Kana"},{"creatorName":"奥野, 一真","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-09"}],"displaytype":"detail","filename":"2019DM0328.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2019DM0328","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/13460/files/2019DM0328.pdf"},"version_id":"e8a087b0-138f-43d5-843e-2ac09a59727d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hypoxia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteosarcoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carbonic anhydrase IX","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitor\\n","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1214"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-09"},"publish_date":"2020-06-09","publish_status":"0","recid":"13460","relation_version_is_last":true,"title":["Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-26T00:45:30.909956+00:00"}