{"created":"2023-06-19T11:43:49.612273+00:00","id":13521,"links":{},"metadata":{"_buckets":{"deposit":"2e3f1b46-d472-4dec-adb3-1b4a4db3aa1e"},"_deposit":{"created_by":16,"id":"13521","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"13521"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013521","sets":["334:608:618:833"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-16","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-12-16"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Previous studies have demonstrated the beneficial activity of activated protein C in allergic diseases including bronchial asthma and rhinitis. However, the exact mechanism of action of activated protein C in allergies is unclear. In this study, we hypothesized that pharmacological doses of activated protein C can modulate allergic inflammation by inhibiting dendritic cells.\nMaterials and methods: Dendritic cells were prepared using murine bone marrow progenitor cells and human peripheral monocytes. Bronchial asthma was induced in mice that received intratracheal instillation of ovalbumin-pulsed dendritic cells.\nResults: Activated protein C significantly increased the differentiation of tolerogenic plasmacytoid dendritic cells and the secretion of type I interferons, but it significantly reduced lipopolysaccharide-mediated maturation and the secretion of inflammatory cytokines in myeloid dendritic cells. Activated protein C also inhibited maturation and the secretion of inflammatory cytokines in monocyte-derived dendritic cells. Activated protein C-treated dendritic cells were less effective when differentiating naive CD4 T-cells from Th1 or Th2 cells, and the cellular effect of activated protein C was mediated by its receptors. Mice that received adoptive transfer of activated protein C-treated ovalbumin-pulsed dendritic cells had significantly less airway hyperresponsiveness, significantly decreased lung concentrations of Th1 and Th2 cytokines, and less plasma concentration of immunoglobulin E when compared to control mice.\nConclusion: These results suggest that dendritic cells mediate the immunosuppressive effect of activated protein C during allergic inflammation.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie Prefecture","subitem_description_type":"Other"},{"subitem_description":"9p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1750号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/JAA.S75261","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Journal of Asthma and Allergy 2015:8 29–37に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Takahiro","creatorNameLang":"en"},{"creatorName":"マツモト, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"松本, 貴博","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-29"}],"displaytype":"detail","filename":"2015DM012.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2015DM012","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/13521/files/2015DM012.pdf"},"version_id":"3d2a404e-94f3-430d-aabe-73ffed24225f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"allergy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"coagulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein C pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Activated protein C modulates the proinflammatory activity of dendritic cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activated protein C modulates the proinflammatory activity of dendritic cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["833"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-07-29"},"publish_date":"2020-07-29","publish_status":"0","recid":"13521","relation_version_is_last":true,"title":["Activated protein C modulates the proinflammatory activity of dendritic cells"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-06T04:43:39.083872+00:00"}