@techreport{oai:mie-u.repo.nii.ac.jp:00013836,
 author = {朴, 恩正 and PARK, Eun Jeong and 島岡, 要 and SHIMAOKA, Motomu},
 month = {May},
 note = {application/pdf, 老化に伴う腸管上皮細胞の遺伝子発現調節の分子機序を明らかにするために、老化マウスモデルを用いて小腸と大腸から回収した上皮細胞のマイクロRNA発現パターンを包括的に分析した結果、有意な発現変化を示す多数のマイクロRNAが見つかった。
また、腸管移行性T細胞のエキソソームにより小腸へのリンパ球ホーミングが抑制される事を確認し、T細胞エキソソームがリンパ球の過剰な腸管組織浸潤を制御する可能性を提示した。, To elucidate the molecular mechanism of regulating comprehensive gene expressions in intestinal epithelial cells in aging, we analyed miRNA profiling of epithelial cells in small and large intestines of aged mice. As a rusult, multiple miRNA were found to be altered by aging.
To understand the rolr of T-cell exosomes tn tissue specific homing of lymhocytes, we isolated the exosomes from the culture of gut-tropic T cells and analyzed in-vivo homing of lymphocytes. We have found that the exosomes possess an ability in begatively regulationg subsequent lymphocyte homing to the gut. This negative effect was considered to be to expression reduction of the ligand molecules important for lymphocyte homing, possibly by exosomal delivery of miRNAs to the gut endothelial cells., 2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書, 16K08581},
 title = {老化に伴う腸上皮バリア機能障害の遺伝子発現調節ネットワークの仕組み},
 year = {2019},
 yomi = {パク, ウンゾン and シマオカ, モトム}
}