{"created":"2023-06-19T11:44:03.246870+00:00","id":13836,"links":{},"metadata":{"_buckets":{"deposit":"62d743bb-9d7b-480f-bc56-e1ba4be60494"},"_deposit":{"created_by":15,"id":"13836","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13836"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013836","sets":["334:627:1692670462461"]},"author_link":["45156","45157"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"老化に伴う腸管上皮細胞の遺伝子発現調節の分子機序を明らかにするために、老化マウスモデルを用いて小腸と大腸から回収した上皮細胞のマイクロRNA発現パターンを包括的に分析した結果、有意な発現変化を示す多数のマイクロRNAが見つかった。\nまた、腸管移行性T細胞のエキソソームにより小腸へのリンパ球ホーミングが抑制される事を確認し、T細胞エキソソームがリンパ球の過剰な腸管組織浸潤を制御する可能性を提示した。","subitem_description_type":"Abstract"},{"subitem_description":"To elucidate the molecular mechanism of regulating comprehensive gene expressions in intestinal epithelial cells in aging, we analyed miRNA profiling of epithelial cells in small and large intestines of aged mice. As a rusult, multiple miRNA were found to be altered by aging.\nTo understand the rolr of T-cell exosomes tn tissue specific homing of lymhocytes, we isolated the exosomes from the culture of gut-tropic T cells and analyzed in-vivo homing of lymphocytes. We have found that the exosomes possess an ability in begatively regulationg subsequent lymphocyte homing to the gut. This negative effect was considered to be to expression reduction of the ligand molecules important for lymphocyte homing, possibly by exosomal delivery of miRNAs to the gut endothelial cells.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K08581","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"朴, 恩正","creatorNameLang":"ja"},{"creatorName":"パク, ウンゾン","creatorNameLang":"ja-Kana"},{"creatorName":"PARK, Eun Jeong","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"島岡, 要","creatorNameLang":"ja"},{"creatorName":"シマオカ, モトム","creatorNameLang":"ja-Kana"},{"creatorName":"SHIMAOKA, Motomu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0017.pdf","filesize":[{"value":"209.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0017","url":"https://mie-u.repo.nii.ac.jp/record/13836/files/2020RP0017.pdf"},"version_id":"cff0a5fa-9db0-454b-ae27-75122da0d621"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"腸管上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"エキソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ホーミング","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"老化に伴う腸上皮バリア機能障害の遺伝子発現調節ネットワークの仕組み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"老化に伴う腸上皮バリア機能障害の遺伝子発現調節ネットワークの仕組み","subitem_title_language":"ja"},{"subitem_title":"Examination of regulatory network profiles for gene expression of intestinal epithelial barrier dysfunction in aging","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13836","relation_version_is_last":true,"title":["老化に伴う腸上皮バリア機能障害の遺伝子発現調節ネットワークの仕組み"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:49:37.642038+00:00"}