{"created":"2023-06-19T11:44:03.464437+00:00","id":13841,"links":{},"metadata":{"_buckets":{"deposit":"1494dd95-3156-43e1-bd76-9bcfe2135e5d"},"_deposit":{"created_by":15,"id":"13841","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13841"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013841","sets":["334:627:1692670462461"]},"author_link":["45189","45190","45191","45192"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"直腸癌腫瘍組織中のPD-L1発現と陳勝病理学的因子との関連では直腸癌組織におけるPD-L1高発現群は、有意に脈管浸潤と相関を認め、さらに術後再発が有意に高率であった。また予後解析では、直腸癌組織中のPD-L1高発現群は、有意にrelapse free survival、ならびにoverall survivalが不良であった。さらに直腸癌周囲の間質に存在するCD8陽性リンパ球数とFoxp3陽性リンパ球数は有意に正の相関を示し、間質浸潤のCD8陽性リンパ球数は腫瘍中のPD-L1高発現群で有意に低値を示した一方、間質浸潤のFoxp3陽性リンパ球数は腫瘍中のPD-L1発現との間に関連を認めなかった。","subitem_description_type":"Abstract"},{"subitem_description":"Immunohistochemical analysis showed that elevated PD-L1 expression in rectal cancer tissues was significantly correlated with presence of lymphovascular invasion and recurrence after curative surgery. Survival curve analysis demonstrated that elevated PD-L1 expression was significantly correlated with poor overall and disease-free survival in rectal cancer patients receiving chemoradiotherapy. Furthermore, number of CD8+tumor infltrative lymphocytes (TILs) was positively correlated with FOXP3+TILs, and CD8+TILs was significantly increased in patients with high PD-L1 expression.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度~2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10532","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ(三重大)","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三枝, 晋","creatorNameLang":"ja"},{"creatorName":"サイグサ, ススム","creatorNameLang":"ja-Kana"},{"creatorName":"Saigusa, Susumu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TOIYAMA, YUJI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 光司","creatorNameLang":"ja"},{"creatorName":"タナカ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TANAKA, KOJI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"KUSUNOKI, MASATO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0022.pdf","filesize":[{"value":"192.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0022","url":"https://mie-u.repo.nii.ac.jp/record/13841/files/2020RP0022.pdf"},"version_id":"4e57ead8-8664-4c2c-9a52-ae4c642f2443"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"直腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"間質","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"直腸癌術前化学放射線療法による癌間質変化と治療抵抗性・再発機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"直腸癌術前化学放射線療法による癌間質変化と治療抵抗性・再発機序の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation for recurrent mechanism in rectal cancer patients after CRT.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13841","relation_version_is_last":true,"title":["直腸癌術前化学放射線療法による癌間質変化と治療抵抗性・再発機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:49:47.479922+00:00"}