{"created":"2023-06-19T11:44:03.508365+00:00","id":13842,"links":{},"metadata":{"_buckets":{"deposit":"146af632-ebaf-48d1-9be9-f3c6fe262207"},"_deposit":{"created_by":15,"id":"13842","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13842"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013842","sets":["334:627:1692670462461"]},"author_link":["45201","45202","45203","45204"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸癌におけるPD-1/PD-L1 axisやCTLA4の臨床的意義を組織と血清を用いて解明することを目的に研究をおこなった。その結果、大腸癌組織中のPD-L1発現やCTLA4発現が有用な再発・予後予測マーカーになるほか、大腸がん患者血清中の可溶性PD-L1濃度やCTLA4濃度が同様に有用な予後予測マーカーとなることがわかった。さらに本研究は胃癌領域にもすすめて解析すると、同様に胃癌患者血清PD-L1が有用な予後予測マーカーとなりうることを同定した。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study was to clarify clinical burden of PD-1-PD-L1 axis in colorectal cancer patients. Interesting, elevated expression of PD-L1 was significantly correlated with poor overall survival and disease-free survival in CRC patients. Furthermore, assessment od CTLA4 cincentration in preperative serum could also identify high-risk population for recurrence and survival in CRC.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10533","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣, 純一郎","creatorNameLang":"ja"},{"creatorName":"ヒロ, ジュンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hiro, Junichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0023.pdf","filesize":[{"value":"387.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0023","url":"https://mie-u.repo.nii.ac.jp/record/13842/files/2020RP0023.pdf"},"version_id":"d3f1e2da-2779-4738-91c9-950445785788"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"PD-1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌における新規免疫治療PD-1/PD-L1経路阻害剤の効果予測マーカーの検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌における新規免疫治療PD-1/PD-L1経路阻害剤の効果予測マーカーの検証","subitem_title_language":"ja"},{"subitem_title":"Clinical burden of PD-L1-PD-1 axis in colorectal cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13842","relation_version_is_last":true,"title":["大腸癌における新規免疫治療PD-1/PD-L1経路阻害剤の効果予測マーカーの検証"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:49:52.172611+00:00"}