{"created":"2023-06-19T11:44:03.596290+00:00","id":13844,"links":{},"metadata":{"_buckets":{"deposit":"1085871e-aea2-4ea2-b688-7f69670814e8"},"_deposit":{"created_by":15,"id":"13844","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13844"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013844","sets":["334:627:1692670462461"]},"author_link":["45234","45235","45236","45237","45238","45239"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-03","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小腸型、小腸大腸型クローン病においてIL-6 IN/CO ratio 手術的再発ハイリスク群同定の有用なpredictive markerであり、術後寛解維持療法選択の一助となる可能性が示唆された。Agingに関わるmiR124, miR137, miR9のmethylationの検討では、miR137は、炎症部と非炎症部で差は認めたものの、再狭窄や瘻孔形成になどのpredictorにはならなかった。プロテオミクスとmiRNAのメチル化解析を統合した結果、有意な関連性を示すことはできなかった。またT細胞受容体レパトア解析での検討には進めなかった。","subitem_description_type":"Abstract"},{"subitem_description":"IL-6 IN/CO ratio could be used as a predictive biomarker to identify high risk population in crohn disease. Furthermore, miR-137 methylation was significantly changed between inflammatory and non-inflammatory tissues of crohn disease. Unfortunately, findings of proteomics was not significantly associated with DNA methylation analysis, and could not progress T-cell analysis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10535","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"アラキ, トシミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 恵一","creatorNameLang":"ja"},{"creatorName":"ウチダ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"UCHIDA, KEIICHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 幹大","creatorNameLang":"ja"},{"creatorName":"イノウエ, ミキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"INOUE, MIKIHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大竹, 航平","creatorNameLang":"ja"},{"creatorName":"オオタケ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"OTAKE, KOHEI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大北, 善基","creatorNameLang":"ja"},{"creatorName":"オオキタ, ヨシキ","creatorNameLang":"ja-Kana"},{"creatorName":"OKITA, YOSHIKI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"KUSUNOKI, MASATO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0025.pdf","filesize":[{"value":"153.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0025","url":"https://mie-u.repo.nii.ac.jp/record/13844/files/2020RP0025.pdf"},"version_id":"b712933e-dc16-40e0-9529-121b6ad9084f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クローン病","subitem_subject_scheme":"Other"},{"subitem_subject":"再発","subitem_subject_scheme":"Other"},{"subitem_subject":"抗TNF抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_scheme":"Other"},{"subitem_subject":"手術","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"クローン病長期寛解維持のための薬剤反応性予測マーカーの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クローン病長期寛解維持のための薬剤反応性予測マーカーの解明","subitem_title_language":"ja"},{"subitem_title":"Biomarker of drug resposiveness as the predictive factor for Crohns disease remission","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13844","relation_version_is_last":true,"title":["クローン病長期寛解維持のための薬剤反応性予測マーカーの解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:49:57.002526+00:00"}