{"created":"2023-06-19T11:44:03.640407+00:00","id":13845,"links":{},"metadata":{"_buckets":{"deposit":"ff4f7d37-d57a-47cc-a3bb-90f900c37d78"},"_deposit":{"created_by":15,"id":"13845","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13845"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013845","sets":["334:627:1692670462461"]},"author_link":["45252"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍特異的微小環境を制御する因子のモノクローナル抗体ないし阻害剤を併用して、腫瘍特異的微小環境を意図的に変化させ、従来の抗がん剤治療効果が、もっとも期待できる環境を再現し、より高い抗腫瘍効果をもたらす治療法を確立する実験計画を考案した結果、放射線耐性株の樹立は困難であり、放射線治療に対する効率的な治療法の確立は困難であったが、放射線治療耐性と同様の耐性を有するとされる低酸素環境下で、Carbonic anhydrase9は、転移および腫瘍浸潤抑制効果を示し、従来の抗がん剤、放射線治療や、光線力学的療法と併用することで、腫瘍微小環境をコントロールし、高い抗腫瘍効果を発揮すると予想された。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study is monoclonal antibodies or inhibitors of tumor microenvironment can control anti-tumor effect of conventional anti-tumor therapy. From previous our studies, to control tumor microenvironment is expected to be necessary for reducing cancer resistance for tumor therapy, We deliberately changed and designed an experimental design to establish a therapeutic method in which the effects of conventional anticancer drugs, radio sensitizers and radiotherapy reproduce the most promising environment and lead to higher antitumor effects. Although establishment of a radiation resistant in vitro condition has been difficult, we find out inhibitor of Carbonic anhydrase 9, which could control hypoxic condition, and it showed the effect of suppressing metastasis and tumor invasion, itself. Moreover, the new agent combined with conventional anticancer agents, radiation therapy or photodynamic therapy exerted a high antitumor effect.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10855","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松原, 孝夫","creatorNameLang":"ja"},{"creatorName":"マツバラ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"MATSUBARA, TAKAO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0026.pdf","filesize":[{"value":"663.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0026","url":"https://mie-u.repo.nii.ac.jp/record/13845/files/2020RP0026.pdf"},"version_id":"0d3cdb6d-3d19-42c1-bb5f-5c2a7f26ac7b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍学","subitem_subject_scheme":"Other"},{"subitem_subject":"Carbonic Anhydrase 9","subitem_subject_scheme":"Other"},{"subitem_subject":"アクリジンオレンジ","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線治療","subitem_subject_scheme":"Other"},{"subitem_subject":"光線力学的療法","subitem_subject_scheme":"Other"},{"subitem_subject":"骨肉腫","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍微小環境","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍微小環境調整因子併用による抗腫瘍治療薬効果改善法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍微小環境調整因子併用による抗腫瘍治療薬効果改善法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of tumor micro environment regulators improving conventional anti-tumor therapy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13845","relation_version_is_last":true,"title":["腫瘍微小環境調整因子併用による抗腫瘍治療薬効果改善法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:49:58.164790+00:00"}