{"created":"2023-06-19T11:44:03.946016+00:00","id":13852,"links":{},"metadata":{"_buckets":{"deposit":"2323e582-7440-4d91-88f4-4df56202b2d5"},"_deposit":{"created_by":15,"id":"13852","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13852"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013852","sets":["334:627:1692670462461"]},"author_link":["45308","45309","45310","45311"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-05","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"敗血症性ショックでは持続する炎症でリモデリングされた大網乳斑から分泌されるエキソソームが、局所ではパラクライン的にマクロファージを炎症促進型M1から炎症抑制型M2に変化させ、さらに循環血液中を流れ遠隔リンパ組織に到達し、全身性にはリンパ球や抗原提示細胞に作用し病的免疫寛容を引き起こすことにより、強力な免疫麻痺を引き起こすという独創的な仮説を検証する。免疫麻痺が起こる敗血症晩期では、大網乳斑が構造的・機能的にリモデリングされることをマウス盲腸結紮穿刺(CLP)モデルで解析する。本提案では、大網乳斑に局在するマクロファージが敗血症病態、特に免疫麻痺に重要な役割を果たしているという仮説を研究した。","subitem_description_type":"Abstract"},{"subitem_description":"We have studied the research hypothesis that the exosomes secreted from the peritoneum omentum milky spots play a critical role in the suppression of immune system during the course of septic shock. Such exosomes are referred to here as tolerosomes. The tolerosomes act in a paracrine manner to local macrophages, thereby skewing the M1-macrophages to the M2-macrophages. In addition, the tolerosomes travel in the circulation and act in a systemic manner to lymphocytes, thereby upregulating PD-1 and/or inducing regulatory cells. In this way, the tolelosomes induce immune paralysis in septic shock. We have tested this hypothesis using mouse CLP model, an established sepsis model. We utilized molecular biological, immunological, and pathohistological approaches to address this important problem.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K15759","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島岡, 要","creatorNameLang":"ja"},{"creatorName":"SHIMAOKA, Motomu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"朴, 恩正","creatorNameLang":"ja"},{"creatorName":"PARK, eun jeong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45309","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡本, 貴行","creatorNameLang":"ja"},{"creatorName":"OKAMOTO, takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 暁子","creatorNameLang":"ja"},{"creatorName":"EGUCHI, akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45311","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0033.pdf","filesize":[{"value":"109.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0033","url":"https://mie-u.repo.nii.ac.jp/record/13852/files/2020RP0033.pdf"},"version_id":"bee4e000-0676-4634-82e5-ba5ae27f983f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"ショック","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫学","subitem_subject_scheme":"Other"},{"subitem_subject":"感染症","subitem_subject_scheme":"Other"},{"subitem_subject":"病理学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腹部臓器大網乳班が分泌するトレロソームが敗血症による免疫麻痺を引き起こす","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腹部臓器大網乳班が分泌するトレロソームが敗血症による免疫麻痺を引き起こす","subitem_title_language":"ja"},{"subitem_title":"The peritoneum omentum exosomes in the septic immune paralysis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13852","relation_version_is_last":true,"title":["腹部臓器大網乳班が分泌するトレロソームが敗血症による免疫麻痺を引き起こす"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:50:16.558387+00:00"}