{"created":"2023-06-19T11:44:04.118090+00:00","id":13856,"links":{},"metadata":{"_buckets":{"deposit":"a1c820bd-b2f9-4496-8f1e-96e2ae765d91"},"_deposit":{"created_by":15,"id":"13856","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13856"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013856","sets":["334:627:1692670462461"]},"author_link":["45325","45326","45327","45328","45329","45330"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"間葉系幹細胞に特異的に発現する中間径フィラメントであるビメンチンの分裂期リン酸化部位に変異を導入した遺伝子改変マウスは、細胞質分裂障害により高効率に細胞がaneuploidy(染色体異数性)を生じることをこれまでに明らかにしてきた。本研究では、本遺伝子改変マウスを用いて、皮膚損傷後の治癒過程を経時的に解析した結果、aneuplod細胞は、多核・多中心体を経てDNA障害を引き起こし細胞老化を引き起こすこと、マウス個体の表現型として老化症状の一つである創傷治癒遅延および皮下脂肪減少を示すことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Intermediate filaments (IFs) are dramatically reorganized during mitosis. Some protein kinases activated in mitosis control spatial and temporal IF reorganization through IF phosphorylation. Here, we analyzed the dorsal skin wound healing in phospho-vimentin-deficient mice. In response to skin injury, vimentin expression was elevated at wound areas of subcutaneous fibroblast in a genotype-independent manner. During the acute phase of wound healing when vimentin expression was relatively high, IF-bridge fornation, binuclation, and extra-centrosome formation was observed specifically in fibroblast of phospho-vimentin-deficient mice. These cellular structures disappeared with decreased expression, leading to increased numbers of aneuploid fibroblasts. Subsequently the fibroblasts exhibited a significant elevation of major senescence-relative markers. These abnormalities resulted in implicated wound healing, one of the premature aging phenotypes.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2018年度科学研究費補助金(基盤研究(A))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15H02398","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲垣, 昌樹","creatorNameLang":"ja"},{"creatorName":"イナガキ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Inagaki, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井澤, 一郎","creatorNameLang":"ja"},{"creatorName":"イザワ, イチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"IZAWA, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 英仁","creatorNameLang":"ja"},{"creatorName":"ゴトウ, ヒデマサ","creatorNameLang":"ja-Kana"},{"creatorName":"GOTO, Hidemasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笠原, 広介","creatorNameLang":"ja"},{"creatorName":"カサハラ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"KASAHARA, Kousuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"猪子, 誠人","creatorNameLang":"ja"},{"creatorName":"イノコ, アキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"INOKO, Akihito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 宏樹","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"TANAKA, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0037.pdf","filesize":[{"value":"115.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0037","url":"https://mie-u.repo.nii.ac.jp/record/13856/files/2020RP0037.pdf"},"version_id":"d08edba5-edcb-47aa-a573-ecf599c1d10a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"染色体異数性","subitem_subject_scheme":"Other"},{"subitem_subject":"中間径フィラメント","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞質分裂","subitem_subject_scheme":"Other"},{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"がん化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"aneuploidy（染色体異数性）と細胞の運命　－がん化、老化、分化－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"aneuploidy（染色体異数性）と細胞の運命　－がん化、老化、分化－","subitem_title_language":"ja"},{"subitem_title":"The fate of aneuploid cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13856","relation_version_is_last":true,"title":["aneuploidy（染色体異数性）と細胞の運命　－がん化、老化、分化－"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:50:26.377775+00:00"}