{"created":"2023-06-19T11:44:04.161029+00:00","id":13857,"links":{},"metadata":{"_buckets":{"deposit":"7242d24c-7415-41e8-b254-384458e9e143"},"_deposit":{"created_by":15,"id":"13857","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13857"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013857","sets":["334:627:1692670462461"]},"author_link":["45343","45344","45345","45346"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"中枢神経系機能性疾患の病態生理にモノアミン及びアミノ酸伝達機構が関与しているが、これら神経伝達だけでは十分に理解できない病態が、中枢神経系機構性疾患に存在する。本研究は、アストロサイトを加えた三者間シナプス伝達モデルを構築し、てんかん、統合失調症、認知症、注意欠陥多動性障害の病態生理に、三者間シナプス伝達が関与していることを明らかにした。アストロサイトのアミノ酸交換輸送系、代謝型グルタミン酸受容体機能が中枢神経系機能性疾患の病態生理に深く関与していることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"To explore the novel pathogenesis and pathophysiology of epilepsy, schizophrenia, attention-deficit hyperactivity disorder (ADHD) and dementia, the present study determined the functional abnormalities of tripartite synaptic transmission using in vivo microdialysis and primary cultured astrocytes. The results of this study suggest that the enhancement of astroglial glutamate/cystine antiporter and metabotropic glutamate receptor contribute to the pathophysiology of epilepsy, schizophrenia, ADHD and dementia.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2018年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15H04892","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 元宏","creatorNameLang":"ja"},{"creatorName":"オカダ, モトヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Motohiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野, 行弘","creatorNameLang":"ja"},{"creatorName":"オオノ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohno, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"植田, 勇人","creatorNameLang":"ja"},{"creatorName":"ウエダ, ユウト","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Yuto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉浦, 嘉泰","creatorNameLang":"ja"},{"creatorName":"スギウラ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugiura, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0038.pdf","filesize":[{"value":"96.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0038","url":"https://mie-u.repo.nii.ac.jp/record/13857/files/2020RP0038.pdf"},"version_id":"c0970ecb-71a2-47ae-96bf-9f166cb3dd39"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アストロサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"三者間伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"},{"subitem_subject":"てんかん","subitem_subject_scheme":"Other"},{"subitem_subject":"認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"ADHD","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"中枢神経系機能性疾患における三者間シナプス伝達機能障害仮説の構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢神経系機能性疾患における三者間シナプス伝達機能障害仮説の構築","subitem_title_language":"ja"},{"subitem_title":"Mechanisms of tripartite synaptic transmission","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13857","relation_version_is_last":true,"title":["中枢神経系機能性疾患における三者間シナプス伝達機能障害仮説の構築"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:50:27.707368+00:00"}