{"created":"2023-06-19T11:44:04.207678+00:00","id":13858,"links":{},"metadata":{"_buckets":{"deposit":"4e3809df-9630-4e04-982c-9ea001881053"},"_deposit":{"created_by":15,"id":"13858","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13858"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013858","sets":["334:627:1692670462461"]},"author_link":["45355","45356","45357","45358"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"炎症関連発がんにおいては、炎症条件下で産生される活性酸素/窒素種によるDNA損傷・突然変異の蓄積やエピゲノム異常が、傷害された組織の修復に出現する幹細胞に生じ、がん進展に寄与すると想定される。\n我々はインジウム化合物がHMGB1-RAGE経路を介して肺上皮細胞に8-nitroguanineを生成することを明らかにした。上咽頭癌組織では、幹細胞マーカーCD44v6およびALDH1A1の陽性率が有意に高く、ニトロ化DNA損傷を確認した。タイ肝吸虫感染胆管癌組織において、がん幹細胞マーカーCD44v9と炎症関連分子COX2およびS100Pの高発現を示した。炎症が幹細胞がん化に寄与することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Under chronic inflammation, reactive oxygen/nitrogen species are produced from both inflammatory cells and epithelial cells. Inflammation-related cancers are characterized by mutagenicDNA lesions, such as 8-nitroguanine, accumulation of mutation, and epigenetic alteration. Tissue injury may activate stem cells for tissue regeneration under inflammatory microenviroment. We demonstrated that indium compounds induced inflammation-specific 8-nitroguanine formation in lung epithelial cells via HMGB1-RAGE pathway. We found the formation of 8-nitroguanine in stem cell marker CD44v6 and ALDH1A1-positive cancer cells. Liker fluke-infested cholangiocarcinoma(CCA) exhibited a higher level of CD44v9 expression than in sporadic CCA tissues, and no CD44v9 staining in the normal bile duct cells. We observed significantly higher expression of inflammation-related markers, S100P and COX-2, in liker fluke-infested CCA tissues. It is suggested that inflammation may associtate cancer stem cells. ","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16H05255","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 真理子","creatorNameLang":"ja"},{"creatorName":"ムラタ, マリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Murata, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川, 伸二","creatorNameLang":"ja"},{"creatorName":"オイカワ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"OIKAWA, shinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平工, 雄介","creatorNameLang":"ja"},{"creatorName":"ヒラク, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"HIRAKU, yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"翠川, 薫","creatorNameLang":"ja"},{"creatorName":"ミドリカワ, カオル","creatorNameLang":"ja-Kana"},{"creatorName":"MIDORIKAWA, kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45358","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0039.pdf","filesize":[{"value":"221.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0039","url":"https://mie-u.repo.nii.ac.jp/record/13858/files/2020RP0039.pdf"},"version_id":"1c93fa74-c1fb-4966-ba13-b714d0091726"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"8-ニトログアニン","subitem_subject_scheme":"Other"},{"subitem_subject":"エピゲノム異常","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症関連発がんにおける幹細胞のがん化機構の解明とその予防法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症関連発がんにおける幹細胞のがん化機構の解明とその予防法の探索","subitem_title_language":"ja"},{"subitem_title":"Carcinogenic mechanisms of stem cells in inflammation-relarted cancer and its prevention","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13858","relation_version_is_last":true,"title":["炎症関連発がんにおける幹細胞のがん化機構の解明とその予防法の探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:50:31.345236+00:00"}