{"created":"2023-06-19T11:44:04.335753+00:00","id":13861,"links":{},"metadata":{"_buckets":{"deposit":"531f69a9-31a5-45fd-8bf6-0b3f48511dd1"},"_deposit":{"created_by":15,"id":"13861","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13861"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013861","sets":["334:627:1692670462461"]},"author_link":["45400","45401","45402","45403","45404"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究の目的は複数の大腸癌発癌過程(前癌病変から癌病変)特異的microRNAs を網羅的解析し、分泌されたそれらのmicroRNAs が血清で検出できるか否かを検証することで、あらゆる癌発生過程を踏まえた散発性大腸癌の血清早期診断マーカーを同定することである。\n実際、我々は血液検体を用いた網羅的解析からmiR-1290を同定し、血清miR-1290発現を用いた大腸癌患者、大腸腺腫患者の診断能はそれぞれAUC=0.83, AUC=0.718であり、極めて有効な大腸癌早期診断血清マーカーであった。さらに大腸癌患者における組織miR-1290高発現なら発現に比べ良好な予後診断マーカーであった。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study was to identify non-invasive diagnostic biomarker for colorectal cancer. Array-based comprehensive analysis demonstrated that miR-1290 was one of candidate for diagnostic marker in CRC patients, and we validated diagnostic potential of serum miR-1290 using serum specimens from patients with adenoma and CRC. Surprisingly, serum miR-1290 could identify patients with adenoma or CRC with high accuracy (AUC=0.83, 0.718, respectively).","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2018年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26293301","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TOIYAMA, YUJI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"INOUE, YASUHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"毛利, 靖彦","creatorNameLang":"ja"},{"creatorName":"モウリ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"MOHRI, YASUHIKO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"沖上, 正人","creatorNameLang":"ja"},{"creatorName":"オキガミ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"OKIGAMI, MASATO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-12"}],"displaytype":"detail","filename":"2020RP0042.pdf","filesize":[{"value":"357.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0042","url":"https://mie-u.repo.nii.ac.jp/record/13861/files/2020RP0042.pdf"},"version_id":"dca46908-4995-45c8-99ac-bd7feffe8c99"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"早期診断","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌発癌pathwayから検証した大腸癌前癌病変の非侵襲的血清診断法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌発癌pathwayから検証した大腸癌前癌病変の非侵襲的血清診断法の確立","subitem_title_language":"ja"},{"subitem_title":"Elucidation of non-invasive biomarker for early dtection of colorectal cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670462461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-12"},"publish_date":"2020-11-12","publish_status":"0","recid":"13861","relation_version_is_last":true,"title":["大腸癌発癌pathwayから検証した大腸癌前癌病変の非侵襲的血清診断法の確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:50:38.226037+00:00"}