{"created":"2023-06-19T11:44:05.617768+00:00","id":13891,"links":{},"metadata":{"_buckets":{"deposit":"f304f857-c5d8-42b4-b10f-60ec3c85b9cd"},"_deposit":{"created_by":15,"id":"13891","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13891"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013891","sets":["631:636:1692684776404"]},"author_link":["45509","45510","45511","45512","45513","45514"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃癌腹膜播種に関与するエピゲノム変化を同定することを目的に研究をおこなった。その結果いくつかのmiRNAをもちいたパネル検査が、原発組織を用いて腹膜播種の有無を同定することが可能となることが判明し、新規バイオマーカーになり得ると考えられた。また、遺伝子発現レベルにおいて注目すると、接着分子の一種であるL1CAMが、癌組織特異的に発現増加するのみならず、病期進展に伴い発現増加し、リンパ節転移・腹膜播種進展と相関し、有用な予後予測マーカーとなることのみならず治療標的にもなりうることを同定した。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study was to identify clinically relevant epigenetic markers for presence of peritoneal dissemination in gastric cancer. Array-based comprehensive analysis demonstrated that miRNA panel could identify GC patients harboring peritoneal dissemination. Furthermore, gene expression analysis demonstrated that increased L1CAM expression was deeply involved in peritoneal metastasis and poor prognosis in gastric cancer patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10497","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今岡, 裕基","creatorNameLang":"ja"},{"creatorName":"イマオカ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Imaoka, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大井, 正貴","creatorNameLang":"ja"},{"creatorName":"オオイ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohi, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉山, 繫幸","creatorNameLang":"ja"},{"creatorName":"ヨシヤマ, シゲユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshiyama, Shigeyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"毛利, 靖彦","creatorNameLang":"ja"},{"creatorName":"モウリ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mohri, Yasuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"2020RP0049.pdf","filesize":[{"value":"699.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0049","url":"https://mie-u.repo.nii.ac.jp/record/13891/files/2020RP0049.pdf"},"version_id":"ee54589c-82b7-411a-af88-b3b1123d057f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腹膜播種","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"snoRNAを用いたあらたな胃癌診断・予後マーカーの確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"snoRNAを用いたあらたな胃癌診断・予後マーカーの確立","subitem_title_language":"ja"},{"subitem_title":"Development of novel epigenetic marker in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684776404"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"13891","relation_version_is_last":true,"title":["snoRNAを用いたあらたな胃癌診断・予後マーカーの確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:50:22.952831+00:00"}