{"created":"2023-06-19T11:44:05.881166+00:00","id":13897,"links":{},"metadata":{"_buckets":{"deposit":"bd9f7507-bd72-4583-8712-cd1204c41a67"},"_deposit":{"created_by":15,"id":"13897","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13897"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013897","sets":["631:636:1692684776404"]},"author_link":["45551"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高一回換気量換気による人工呼吸は肺障害をきたす。ラットの敗血症に高一回換気量換気を行うことで生じる肺障害をrTMが抑制するか確認した。ラットを全身麻酔下に、Cecal ligation and puncture(CLP)による敗血症のモデルを作成し、Low tidal volume(6ml/Kg)とhigh tidal volume(35ml/Kg)の1回換気量で人工呼吸管理を2時間行い肺障害を来たし、rTMを投与し、その効果を確認した。高一回換気量換気によりPa02低下とBALF中のタンパク質の上昇を認めたが、rTM投与を行っても、Pa02、BALF中のタンパク量に変化を認めなかった。","subitem_description_type":"Abstract"},{"subitem_description":"High tidal ventilation with inflammation causes ventilator-induced lung injury(VILI). This study aimed to investigate the preventive effect of rTM on VILI in sepsis caused by HV ventilation. A total of 46 adult male rats were subcutaneously administered either 3mg/Kg of rTM or saline. Twelve hours later, the rats were underwent cecal ligation and puncture(CLP). At 2h after this procedure, tha rats were placed on a ventilator set at either low tidal volume [(LV)6ml/Kg] or high tidal volume (HV 35ml/kg) ventilation for another 2h. After 2h of mechanical ventilation, the Pa02 was significantly lower and BALF protein was significantly higher in HV rats than in LV rats. The rTM did not improve oxygenation or BALF protein levels. Also in HV rats, lung tissue IL6 and MCP-1 mRNA levels were significantly higher in the rTM-treated rats. rTM does not improve oxygenation in a non-DIC, CLP-pretreated, high-tidal-ventilation rat model.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2018年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K20385","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩下, 義明","creatorNameLang":"ja"},{"creatorName":"イワシタ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwashita, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45551","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"2020RP0055.pdf","filesize":[{"value":"256.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0055","url":"https://mie-u.repo.nii.ac.jp/record/13897/files/2020RP0055.pdf"},"version_id":"38c3396b-1270-42a9-a83b-83d503abdc9b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"人工呼吸関連肺障害","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"リコンビナントトロンボモジュリン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"敗血症における人工呼吸関連肺損傷に対するトロンボモジュリンの抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"敗血症における人工呼吸関連肺損傷に対するトロンボモジュリンの抑制効果","subitem_title_language":"ja"},{"subitem_title":"Effect of Recombinat Human Thrombomodulin on Ventilator-Induced Lung Injury in Septic Rats","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684776404"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"13897","relation_version_is_last":true,"title":["敗血症における人工呼吸関連肺損傷に対するトロンボモジュリンの抑制効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:50:36.706471+00:00"}