@techreport{oai:mie-u.repo.nii.ac.jp:00013899, author = {城山, 隆 and Shiroyama, Takashi and 前田, 正幸 and Maeda, Masayuki}, month = {May}, note = {application/pdf, 双極性障害に伴う緊張病症状の白質障害、局所脳容積について、TBSS;Tract-Based Spatial Statistics、skeletonized-ROI、VBM; Voxel Based Morphometryを用いて調べた。緊張病症状を伴うケースでは前頭前野眼窩部、島、鈎状束、小脳、脳梁体部、内側前頭前野、内包前脚、上放線冠の白質微細構造変化が示唆された。主に鈎状束によって連絡される前頭前野眼窩部―島-扁桃体の形成するネットワークは、緊張病症状の情動・不安と行動障害の病理に重要な役割を果たしていると考えられた。, White matter abnormalities and regional brain volume alterations in catatonic symptoms associated with bipolar disorder were investigated with TBSS; Tract-Based Spatial Statistics, skeletonized-ROI, and VBM; Voxel Based Morphometry. Present results suggested altered white matter microstructures in orbital prefrontal area, insula, uncinate fasciculus, cerebellum, body of corpus callosum, medial prefrontal area, anterior limb of internal capsule, and superior corona radiata. Orbital prefrontal area-insula-amygdala network which is connected mainly by uncinate fasciculus is considered to play an important role for pathophysiology of emotion- anxiety and behavioral disturbances in catatonic symptoms., 2015年度~2018年度科学研究費補助金(基盤研究(C))研究成果報告書, 15K09863}, title = {緊張病症状の病態仮説の拡散テンソル画像による形態学的検証}, year = {2019}, yomi = {シロヤマ, タカシ and マエダ, マサユキ} }