{"created":"2023-06-19T11:44:06.013416+00:00","id":13900,"links":{},"metadata":{"_buckets":{"deposit":"5d2246e8-6577-4292-8908-a4012852e4c8"},"_deposit":{"created_by":15,"id":"13900","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13900"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013900","sets":["631:636:1692684776404"]},"author_link":["45563","45564","45565","45566","45567"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"基礎的研究で15病変のice ballの視認性を検討し、軟部腫瘍では全病変で明瞭（CT値が0HU前後まで低下）が、骨腫瘍では明瞭から全く不明まで分散（CT値>130HU）。ice ballに対する腫瘍壊死の容積率は平均74%。\n臨床試験は20例（男性15女性5、平均64.8才；52-85、平均最大腫瘍径2.9cm；1.0-4.7）を登録。主要評価項目の安全性では 2例（10%）にGrade-3末梢神経障害の重篤な合併症が出現。副次評価項目で、有痛性3症例においては全例（100%）で除痛効果が得られて無痛となり、局所腫瘍壊死率は19例（95%）でCRまたはPRが得られ、5年生存率は27.4%。","subitem_description_type":"Abstract"},{"subitem_description":"This prospective study enrolled 20 subjects (15 male, 5 female) with mean age of 64.8 years (range, 52-85 years) having malignant musculoskeletal tumors with a mean maximum diameter of 2.9 cm (range, 1.0-4.7cm). No adverse event was found in 18 of 20 patients (90%). Grade-3 peripheral nervous system disorder was fund in 2 patients (10%, 2/20). NRS scores fell down to 0 in 3 of 3 patients (100%) who had painful musculoskeletal tumors. Tumor response (complete or partial response) was achieved in 19 of 20 patients (95%) during follow-up period. The 5-year overall survival rate and the median survival time were 27.4% and 4.4 years, respectively.\nIn conclusion, cryoablation for musculoskeletal tumors is relatively safe, feasible, and useful therapeutic option for controlling tumors and for relieving pain, which can engender prolonged patient survival.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2018年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K09952","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中塚, 豊真","creatorNameLang":"ja"},{"creatorName":"ナカツカ, アツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakatsuka, Atsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山門, 亨一郎","creatorNameLang":"ja"},{"creatorName":"ヤマカド, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamakado, Koichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松峯, 昭彦","creatorNameLang":"ja"},{"creatorName":"マツミネ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumine, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"広川, 佳史","creatorNameLang":"ja"},{"creatorName":"ヒロカワ, ヨシフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirokawa, Yoshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山中, 隆嗣","creatorNameLang":"ja"},{"creatorName":"ヤマナカ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamanaka, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"2020RP0058.pdf","filesize":[{"value":"87.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020RP0058","url":"https://mie-u.repo.nii.ac.jp/record/13900/files/2020RP0058.pdf"},"version_id":"db0b3303-e5e8-4233-9ff8-ec9e79949f0f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cryoablation","subitem_subject_scheme":"Other"},{"subitem_subject":"musculoskeletal tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"凍結治療","subitem_subject_scheme":"Other"},{"subitem_subject":"骨軟部腫瘍","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨軟部腫瘍に対するＣＴガイド下凍結療法：基礎的研究と臨床試験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨軟部腫瘍に対するＣＴガイド下凍結療法：基礎的研究と臨床試験","subitem_title_language":"ja"},{"subitem_title":"Safety and Clinical Outcomes of Percutaneous Cryoablation for Musculoskeletal Tumors: a Phase-II Clinical Study","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684776404"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"13900","relation_version_is_last":true,"title":["骨軟部腫瘍に対するＣＴガイド下凍結療法：基礎的研究と臨床試験"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:50:43.927395+00:00"}