{"created":"2023-06-19T11:44:10.811191+00:00","id":14011,"links":{},"metadata":{"_buckets":{"deposit":"5d6e9798-25d1-4d51-95ef-23fd6412b77c"},"_deposit":{"created_by":13,"id":"14011","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"14011"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014011","sets":["334:335:354:1280"]},"author_link":["45885"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"三重看護学誌"},{"bibliographic_title":"Ｍie Nursing Journal","bibliographic_titleLang":"en"}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Fibrosis associated with chronic inflammation occurs in various organs, such as liver, lung, and kidney, and leads to organ failure and high mortality. However, effective treatment for fibrosis is still lacking. Both fibroblasts and monocyte-derived cells, including macrophages and fibrocytes, are thought to play a pivotal role in fibrosis. C-C chemokine receptor 2 (CCR2)-positive monocytes infiltrate the injured tissues, in which monocyte chemoattractant protein-1 (MCP-1), one of the most important chemokine, is produced and released, and differentiate into macrophages and fibrocytes. Although a small part of fibrocytes can directly give rise to myofibroblasts in the presence of cytokines, including transforming growth factor-β or interleukin 13, most of them stimulate resident fibroblasts to transform into myofibroblasts, which produce a large amount of extracellular matrix proteins, and indirectly induce the organ fibrosis. Blockade of CCR2/MCP-1 pathway inhibited not only infiltration of CCR2-positive monocytes into injured colon but also progression of colon fibrosis and tumorigenesis in colitis-associated cancer model. New treatments for fibrosis can be developed on the basis of crosstalk between monocyte-derived cells and resident fibroblasts.","subitem_description_type":"Abstract"},{"subitem_description":"慢性炎症に伴い発生する線維化は肝臓，肺臓，腎臓など多くの臓器で認められ，最終的に不可逆的な機能不全に陥って死に至る．しかしながら線維症治療法は十分ではない．線維化において重要な役割を演じるのが線維芽細胞と単球由来細胞である．炎症部位ではMCP-1などのケモカインが産生され，そこにCCR2陽性単球が侵入しマクロファージや線維細胞に分化する．線維細胞の一部はTGF-βやIL-13などのサイトカインにより筋線維芽細胞に分化しうるが，多くは組織に常在する線維芽細胞を刺激して筋線維芽細胞に分化させ大量の細胞外マトリックスを産生させることにより線維化を誘導する．大腸炎関連大腸癌モデルマウスにおいてCCR2/MCP-1経路の阻害によりCCR2陽性単球の傷害部位への侵入が抑制され，大腸線維化ならびに腫瘍形成が有意に抑制された．このような単球系細胞と常在線維芽細胞とのクロストークに着目した新規線維化治療の開発が期待される．","subitem_description_type":"Abstract"}]},"item_4_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学大学院医学系研究科看護学専攻"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-6983","subitem_source_identifier_type":"PISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11353824","subitem_source_identifier_type":"NCID"}]},"item_4_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_4_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガクダイガクインイガクケイケンキュウカカンゴガクセンコウ"}]},"item_4_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper / 紀要論文"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桝屋, 正浩","creatorNameLang":"ja"},{"creatorName":"マスヤ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Masuya, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-27"}],"displaytype":"detail","filename":"01桝屋.pdf","filesize":[{"value":"426.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01桝屋","url":"https://mie-u.repo.nii.ac.jp/record/14011/files/01桝屋.pdf"},"version_id":"27afb80b-d289-474f-85a9-9af2c0c134bc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"線維化","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR2/MCP-1経路","subitem_subject_scheme":"Other"},{"subitem_subject":"単球","subitem_subject_scheme":"Other"},{"subitem_subject":"線維細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR2/MCP-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"臓器線維症発症における単球系細胞の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臓器線維症発症における単球系細胞の役割","subitem_title_language":"ja"},{"subitem_title":"Role of monocyte-derived cells in the development of organ fibrosis","subitem_title_language":"en"}]},"item_type_id":"4","owner":"13","path":["1280"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-27"},"publish_date":"2021-04-27","publish_status":"0","recid":"14011","relation_version_is_last":true,"title":["臓器線維症発症における単球系細胞の役割"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-10-04T06:23:31.575868+00:00"}