{"created":"2023-06-19T11:44:29.671714+00:00","id":14432,"links":{},"metadata":{"_buckets":{"deposit":"099c4303-5d0d-4c15-81b1-ebb0ff655dfe"},"_deposit":{"created_by":16,"id":"14432","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"14432"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014432","sets":["334:608:618:621"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-10","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-12-10"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Thrombotic microangiopathy (TMA) is caused by various conditions, such as decreased a ADAMTS13 level, activated or injured vascular endothelial cells or activated platelets. This study examined the soluble platelet glycoprotein VI (sGPVI) levels in patients with TMA to evaluate the activation of platelets in thrombotic states. \nMaterials and methods: The plasma levels of sGPVI, ADAMTS13 activity, von Willebrand factor (VWF) and VWF propeptide (VWFpp) were measured in patients with TMA. \nResults: The plasma levels of sGPVI were significantly higher in postoperative patients, patients with TMA and those with disseminated intravascular coagulation (DIC) than in those without thrombosis. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 and those were significantly reduced after plasma exchange. \nConclusion: The measurement of sGPVI level is therefore considered to be important for the diagnosis and evaluation of TMA. ","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Departments of Hematology and Oncology, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan","subitem_description_type":"Other"},{"subitem_description":"5p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第975号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.thromres.2013.11.023   \n ","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Thrombosis Research, 133(2014):440-444に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamashita, Yoshiki","creatorNameLang":"en"},{"creatorName":"ヤマシタ, ヨシキ","creatorNameLang":"ja-Kana"},{"creatorName":"山下, 芳樹","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-13"}],"displaytype":"detail","filename":"2014DM014.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2014DM014","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/14432/files/2014DM014.pdf"},"version_id":"ecf58d47-7cf9-4293-95cb-2735141175d4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TMA","subitem_subject_scheme":"Other"},{"subitem_subject":"Platelet activation","subitem_subject_scheme":"Other"},{"subitem_subject":"ADAMTS13","subitem_subject_scheme":"Other"},{"subitem_subject":"sGPVI","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["621"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-13"},"publish_date":"2021-12-13","publish_status":"0","recid":"14432","relation_version_is_last":true,"title":["Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-07T06:31:40.199314+00:00"}