{"created":"2023-06-19T11:44:32.010946+00:00","id":14486,"links":{},"metadata":{"_buckets":{"deposit":"ca05bd52-dbd9-4028-ba1f-0a8210c811be"},"_deposit":{"created_by":15,"id":"14486","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14486"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014486","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究はE4-K4コイルドコイル型ペプチドを用い、前立腺癌幹細胞を標的としたエンドサイトーシスを回避する抗がん剤送達技術の開発を行った。4回繰り返しKペプチドと癌幹細胞特異的表面抗原CD44結合ペプチドを結合したペプチド(K4-CD44BP)を合成し、癌幹細胞に投与した後、Eペプチド結合リポプレックス(E4リポプレックス)を投与・試験した。この標的癌幹細胞膜との融合を、細胞培養試験・ヒト癌幹細胞移植ゼブラフィッシュ・マウスを用いて検討した。癌幹細胞を標的とした薬物送達はすべての試験系で確認できたが、マウスへの3週間投与試験の結果、その抗がん作用に明らかな改善は認められなかった。","subitem_description_type":"Abstract"},{"subitem_description":" In this study, we developed an anticancer drug delivery technology targeting prostate cancer stem cells to avoid endocytosis using the aforementioned E4-K4 coiled -coil peptides. We synthesized a peptide (K4-CD44BP) conjugated with a K-peptide and a cancer stem cell-specific surface antigen CD44-binding peptide four times and administered it to cancer stem cells followed by an E-peptide binding lipoplex (E4 lipoplex). This fusion with the target cancer stem cell membrane was investigated using cell culture assays and human cancer stem cell transplantation in zebrafish and mice. Targeted drug delivery of cancer stem cells was confirmed in all of the above test systems, but no apparent improvement in their anticancer activity was observed in a 3-week study administered to mice.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K08590","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 康人","creatorNameLang":"ja"},{"creatorName":"シマダ, ヤスヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Yasuhito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"市原, 佐保子","creatorNameLang":"ja"},{"creatorName":"イチハラ, サホコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichihara, Sahoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小出, 裕之","creatorNameLang":"ja"},{"creatorName":"コイデ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Koide, Hiroyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0020.pdf","filesize":[{"value":"354.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0020","url":"https://mie-u.repo.nii.ac.jp/record/14486/files/2021RP0020.pdf"},"version_id":"4e87fb2c-f38c-471d-9c3c-b5ea4cbccab0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リポソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチド修飾","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼブラフィッシュ","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"エンドサイトーシス非依存性膜融合ペプチドを用いた癌幹細胞ドラッグデリバリー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エンドサイトーシス非依存性膜融合ペプチドを用いた癌幹細胞ドラッグデリバリー","subitem_title_language":"ja"},{"subitem_title":"Endocytosis-independent membrane fusion peptides for cancer stem cell drug delivery","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14486","relation_version_is_last":true,"title":["エンドサイトーシス非依存性膜融合ペプチドを用いた癌幹細胞ドラッグデリバリー"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:31:48.170746+00:00"}