{"created":"2023-06-19T11:44:32.195588+00:00","id":14490,"links":{},"metadata":{"_buckets":{"deposit":"a3dd6612-aa23-435b-90f8-173d803af3d3"},"_deposit":{"created_by":15,"id":"14490","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14490"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014490","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-30","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"障害幹細胞からは病態情報を包埋した細胞外小胞が放出される。本研究では、アルコール性肝障害における肝由来の細胞外小胞が動脈硬化症を誘発する機構の検討および細胞外小胞成分の解析を行った。アルコール性肝炎マウスモデルでは動脈硬化症の症状は比較的軽微にとどまったものの、骨格筋においてミトコンドリア巨大化など様々な変化が生起することを見出し、これらの臓器間病態クロストークに関与する細胞外小胞成分を同定した。アルコール性肝障害では動脈硬化症のみならずサルコペニアにおいても幹細胞由来の細胞外小胞が臓器間病態情報伝播体として重要な役割を果たす可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"Alcoholic liver disease (ALD) is strongly associated with arteriosclerosis. We have reported that damaged hepatocytes release extracellular vesicles (EVs) in ALD mice, thus we hypothesized that hepatocyte-derived EVs carry pathological information, such as cellular proteins and microRNAs, causing development of arteriosclerosis. In this study, we investigate the molecular mechanism of arteriosclerosis by hepatocyte-derived EVs. Using the alcoholic hepatitis mouse model, we observed the mild arteriosclerosis and abnormalities in muscle, suggesting that ALD is not only associated with arteriosclerosis but muscle damage. We detected proteins and microRNAs in hepatocyte-derived EVs that are associated with arteriosclerosis and muscle damage. We conclude that hepatocyte-derived EVs may contribute the progression of arteriosclerosis and muscle damage.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K09419","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹井, 謙之","creatorNameLang":"ja"},{"creatorName":"タケイ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takei, Yoshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"江口, 暁子","creatorNameLang":"ja"},{"creatorName":"エグチ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 憲彦","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ノリヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Norihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長谷川, 浩司","creatorNameLang":"ja"},{"creatorName":"ハセガワ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Hiroshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0024.pdf","filesize":[{"value":"398.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0024","url":"https://mie-u.repo.nii.ac.jp/record/14490/files/2021RP0024.pdf"},"version_id":"e88199a0-7032-4719-b455-2feabf5a900a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アルコール性肝障害","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外小胞","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アルコール性肝障害における動脈硬化発症機序の解明：肝由来小胞体封入病態情報の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルコール性肝障害における動脈硬化発症機序の解明：肝由来小胞体封入病態情報の関与","subitem_title_language":"ja"},{"subitem_title":"Investigation of arteriosclerosis associating with liver derived extracellular vesicles in alcohlic liver disease","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14490","relation_version_is_last":true,"title":["アルコール性肝障害における動脈硬化発症機序の解明：肝由来小胞体封入病態情報の関与"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:31:59.005749+00:00"}