{"created":"2023-06-19T11:44:32.242852+00:00","id":14491,"links":{},"metadata":{"_buckets":{"deposit":"aa5e359d-5fe1-48dd-a8ef-1d6374d077d3"},"_deposit":{"created_by":15,"id":"14491","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14491"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014491","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-08","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、右心カテーテル検査で安静時平均肺動脈圧(MPAP)は肺高血圧域に達していない膠原病患者39例を対象に運動負荷を行いMPAPが30mmHg以上に上昇した31例を薬物投与E群と非投与N群間に割り振った。2年間にわたり運動負荷時の血行動態各指標の変化を観察したところ、肺動脈のリモデリングの程度を反映すると考えられる最大運動負荷時のMPAP増加量を心拍出量の増加量で除した指標において、E群で有意に改善したのに対しN群では増悪傾向を認め、早期薬物治療介入が肺血管における病勢進行抑制に効果的である可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":" Pulmonary arterial hypertension associated with connective tissue disease (CTD-PAH) is a rapidly progressive disorder and has a poor prognosis. The purpose of this study is to investigate the effectiveness of early pharmacological intervention in borderline PAH. We performed right heart catheterization (RHC) during exercise in 31 patients with borderline CTD-PAH. Comparison of hemodynamic data between medication group and non-medication group was evaluated by follow-up RHC during exercise performed after 2 years. ΔMPAP (mmHg) (MPAP at maximal exercise-MPAP at rest) / ΔCO (CO at maximal exercise - CO at rest) significantly improved in medication group, but tended to worsen in non-medication group. Early pharmacological intervention might have the potential to prevent the pulmonary vascular remodeling for EIPAH with CTD.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K09552","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 典一","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ノリカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Norikazu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0025.pdf","filesize":[{"value":"102.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0025","url":"https://mie-u.repo.nii.ac.jp/record/14491/files/2021RP0025.pdf"},"version_id":"2be80918-592f-4028-b049-fccd5acef011"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧症","subitem_subject_scheme":"Other"},{"subitem_subject":"早期治療介入","subitem_subject_scheme":"Other"},{"subitem_subject":"運動負荷","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膠原病関連境界型肺高血圧症の進行予測因子の同定と早期治療効果に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膠原病関連境界型肺高血圧症の進行予測因子の同定と早期治療効果に関する検討","subitem_title_language":"ja"},{"subitem_title":"Evaluation of the effect of early treatment for collagen associated borderline pulmonary arterial hypertension","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14491","relation_version_is_last":true,"title":["膠原病関連境界型肺高血圧症の進行予測因子の同定と早期治療効果に関する検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:31:58.905032+00:00"}