{"created":"2023-06-19T11:44:32.289722+00:00","id":14492,"links":{},"metadata":{"_buckets":{"deposit":"cf747f23-f0c8-4b70-bc25-071512332641"},"_deposit":{"created_by":15,"id":"14492","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14492"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014492","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"MUC5B遺伝子の単塩基多型であるrs35705950は特発性肺線維症との関連性が示されている。本研究ではヒトrs35705950の過剰発現トランジェニック(TG)マウスを用いて肺線維症マウスモデルを作製し、MUC5B遺伝子が肺線維症の病態形成に関与するかを検討した。マウスの背部の皮下にブレオマイシンを投与し、肺線維症モデルを作製した。その結果、野生型マウスではMUC5B-TGマウスに比べ、肺組織中の炎症性細胞数、ヒドロキシプロリンの含量、成長因子の発現、細胞外基質の蓄積は有意に上昇した。以上の結果より、肺線維症に対してMUC5Bが防御的であることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":" Several studies reported the association of MUC5B promoter variant rs35705950 with idiopathic pulmonary fibrosis. Here we developed a transgenic mouse overexpressing the human MUC5B promoter variant rs35705950 and evaluated whether its overexpression correlates with the development of experimental pulmonary fibrosis. We compared the degree of lung fibrosis and fibrotic markers between wild type and rs35705950 transgenic mice. Lung fibrosis was induced by bleomycin using osmotic minipumps. The number of inflammatory cells, the hydroxyproline content, the concentration of extracellular matrix proteins and the level of transforming growth factor-betal in the lungs were significantly enhanced in wild-type mice compared to MUC5B transgenic mice receiving bleomycin. The results of this suggest that overexpression of MUC5B protein in the lungs protects against bleomycin-induced pulmonary fibrosis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K09611","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田口, 修","creatorNameLang":"ja"},{"creatorName":"タグチ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Taguchi, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gabazza, Corina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"戸田, 雅昭","creatorNameLang":"ja"},{"creatorName":"トダ, マサアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Toda, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小林, 哲","creatorNameLang":"ja"},{"creatorName":"コバヤシ, テツ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Tetsu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0026.pdf","filesize":[{"value":"625.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0026","url":"https://mie-u.repo.nii.ac.jp/record/14492/files/2021RP0026.pdf"},"version_id":"d26c26aa-b7b6-4dac-afdd-b09baa03f2f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺線維症","subitem_subject_scheme":"Other"},{"subitem_subject":"ムチン","subitem_subject_scheme":"Other"},{"subitem_subject":"トランジェニックマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"ブレオマイシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"MUC5B過剰発現マウスを用いた肺線維症の病態解明と治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MUC5B過剰発現マウスを用いた肺線維症の病態解明と治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of novel therapeutic approaches for pulmonary fibrosis using MUC5B overexpressing mice","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14492","relation_version_is_last":true,"title":["MUC5B過剰発現マウスを用いた肺線維症の病態解明と治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:32:04.670551+00:00"}