{"created":"2023-06-19T11:44:32.383239+00:00","id":14494,"links":{},"metadata":{"_buckets":{"deposit":"80702877-f442-4f19-a6dc-b724ff588d2b"},"_deposit":{"created_by":15,"id":"14494","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14494"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014494","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-27","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自閉症は、コミュニケーション障害・社会性の障害・常同行動といった中核症状のほか、感覚過敏など感覚の問題がしばしば合併する。本研究では、ヒト自閉症診断への応用を目指すことを目的として、自閉症モデルラットを用いて聴覚の中枢神経系の中継核異常の機能的意義、特に音源定位に関わる神経核に着目して形態学的解析を行った。\n音源定位に関わる神経核である外側上オリーブ、内側上オリーブ、台形体核においては自閉症モデルラットでシナプス関連分子の発現変化が見られ、神経回路に異常を引き起こしていることが示唆された。自閉症モデルラットでは音刺激で台形体核の細胞応答異常が見られたが、音源の方向による差は見いだされなかった。","subitem_description_type":"Abstract"},{"subitem_description":" Autism spectrum disorders is characterized by impairment in social interaction; communication abnormalities; and limited activity and curiosity. Sensory hypersensitivity is frequently observed with ASD. In this study, I performed morphological analysis of ASD model rats, focusing on the functional significance of neural circuit in the auditory central nervous system, especially sound localization.\nSuperior olivary complex nuclei (lateral olivary nucleus, medial olivary nucleus, and medial nucleus of the trapezoid body) are associated with sound localization. In these nuclei, abnormal expression of synapse-associated molecules were observed in ASD model rats, suggesting an abnormality in neural circuits. Following sound stimulus, altered neuronal activity of the medial nucleus of the medial nucleus of the trapezoid body. However, the difference by the direction of the sound source was not found.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"著者「江藤みちる」の報告書での表記は「江藤みちる(伊田みちる)」","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K10050","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"江藤, みちる","creatorNameLang":"ja"},{"creatorName":"Ida-Eto, Michiru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0028.pdf","filesize":[{"value":"82.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0028","url":"https://mie-u.repo.nii.ac.jp/record/14494/files/2021RP0028.pdf"},"version_id":"73a74d86-e780-4dcd-aa2a-9d77b3d755a8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自閉症","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"サリドマイド","subitem_subject_scheme":"Other"},{"subitem_subject":"聴覚","subitem_subject_scheme":"Other"},{"subitem_subject":"脳幹","subitem_subject_scheme":"Other"},{"subitem_subject":"抑制性ニューロン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自閉症モデルラットを用いた自閉症における音源定位能の基盤的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症モデルラットを用いた自閉症における音源定位能の基盤的研究","subitem_title_language":"ja"},{"subitem_title":"Mechanism of sound localization in human autism using autism model rats","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14494","relation_version_is_last":true,"title":["自閉症モデルラットを用いた自閉症における音源定位能の基盤的研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:32:09.528069+00:00"}