{"created":"2023-06-19T11:44:32.853100+00:00","id":14504,"links":{},"metadata":{"_buckets":{"deposit":"7742c4dc-c760-4335-903e-a43daa423b24"},"_deposit":{"created_by":15,"id":"14504","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14504"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014504","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-29","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"最近、TRPチャネルというCaを細胞内に入れる受容体が肺にも存在することが発見された。\n本研究では、慢性低酸素暴露肺高血圧ラットでは、肺組織のTRPV4mRNA発現が亢進していた。閉塞性肺血管病変をもたらす、Sugen肺高血圧ラットの摘出肺動脈およびBMP2Rノックアウトラット+モノクロタリン+投与の摘出肺動脈では、TRPV4刺激薬により、肺動脈血管の収縮が亢進していることを見出した。これらの結果は、モノクロタリン肺高血圧モデルでは認められなかった。この収縮亢進に見合うTRPV4mRNAの増加は肺組織全体では、検出できなかった。今後は、肺血管平滑筋や内皮細胞での発現を検討する必要がある。","subitem_description_type":"Abstract"},{"subitem_description":" Isolated pulmonary arterial vascular contraction was accentuated by TRPV4 channel stimulator in experimantal pulmonaryn ypertesion in rat, where the PH was induced Sugen-chronic hypoxia model and BMP2R knockout rat model injected with monocrotaline (60mg). In lungs from monocrotaline-induced pulmonary nypertension, BMP2R knockout rat and Sugen-hypoxia-induced pulmonary hypertension, no significant changes in lung TRPV4 mRNA levels was detected compared to contol rats of each model. In chronic hypoxia model, 14days after the hypoxia exposure showed significant increase in TRPV4 mRNA levels compared to the levels of 2 days hypoxic exposure. Since whole lung mRNA could not differentiate the sources such as endothelial cells, amooth muscle cell and/or other cells, further studies will be necessary to focus solrly to pulmonary smooth muscle cells and endothelial cells.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K11075","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸山, 一男","creatorNameLang":"ja"},{"creatorName":"Maruyama, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"澤田, 博文","creatorNameLang":"ja"},{"creatorName":"Sawada, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"張, 尓泉","creatorNameLang":"ja"},{"creatorName":"Zhang, Erquan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丸山, 淳子","creatorNameLang":"ja"},{"creatorName":"Maruyama, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三谷, 義英","creatorNameLang":"ja"},{"creatorName":"Mitani, Yoshihide","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0038.pdf","filesize":[{"value":"265.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0038","url":"https://mie-u.repo.nii.ac.jp/record/14504/files/2021RP0038.pdf"},"version_id":"24eac3a1-544b-41e6-a0dd-a9bbb1ff982b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"TRPV","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"実験的肺高血圧に対するTRPVチャネルを標的とした解析と治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験的肺高血圧に対するTRPVチャネルを標的とした解析と治療","subitem_title_language":"ja"},{"subitem_title":"Analysis of TRPV channel in experimantal pulmonary hypertension and treatment","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14504","relation_version_is_last":true,"title":["実験的肺高血圧に対するTRPVチャネルを標的とした解析と治療"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:32:33.374871+00:00"}