{"created":"2023-06-19T11:44:33.130729+00:00","id":14510,"links":{},"metadata":{"_buckets":{"deposit":"5c2c262e-b6f0-4d07-810b-b486e62b720e"},"_deposit":{"created_by":15,"id":"14510","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14510"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014510","sets":["334:627:1692670486782"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"網膜電図(ERG)の最初の陰性波であるa 波の起源は主に視細胞であると信じられてきた。しかしながら、視細胞が重度に変性した状態でもこの起源が正しいかどうかは知られていない。我々は、ウサギの網膜変性動物モデルを用いて、視細胞が変性した状態におけるERGのa波の起源を研究した。高齢のTgウサギを使用し、3次ニューロンを抑制する薬物を注射した前後でERGのa波を記録した。その結果、進行した視細胞変性を有するTgウサギから記録される小さなa波は、TTXとNMDAでほぼ完全に消失することがわかった。以上の結果により、進行した視細胞変性網膜ではa波の起源に3次ニューロンが多く含まれることがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"It is widely believed that the origin of the a-wave of electroretinogram (ERG) is mainly the photoreceptors. However, it was unknown this hypothesis is really true in the retina with severe photoreceptor degeneration. In this study, we studied the origin of the a-wave in the retina with severe photoreceptor degeneration using transgenic (Tg) rabbit model of photoreceptor degeneration. Aged Tg rabbit model of 2-3 years were used. The a-waves were recorded before and after intravitreal injection of tetrodotoxin (TTX)and N-methyl-D-aspartic acid (NMDA) in aged Tg rabbits. We found that the small a-wave, which was seen in in aged Tg rabbits, was nearly completely suppressed after intravitreal injection of TTX and NMDA. These results suggested that the small a-waves which are seen in patients with severe photoreceptor degeneration, like retinitis pigmentosa, can originate from retinal third-order neurons.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K19721","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 峰生","creatorNameLang":"ja"},{"creatorName":"コンドウ, ミネオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Mineo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"杉本, 昌彦","creatorNameLang":"ja"},{"creatorName":"スギモト, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Masahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"生杉, 謙吾","creatorNameLang":"ja"},{"creatorName":"イケスギ, ケンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikesugi, Kengo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松原, 央","creatorNameLang":"ja"},{"creatorName":"マツバラ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsubara, Hisashi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-19"}],"displaytype":"detail","filename":"2021RP0044.pdf","filesize":[{"value":"237.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0044","url":"https://mie-u.repo.nii.ac.jp/record/14510/files/2021RP0044.pdf"},"version_id":"93e3eda2-b0c7-44c3-ada2-33d278d9ac9a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"網膜電図","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ","subitem_subject_scheme":"Other"},{"subitem_subject":"a波","subitem_subject_scheme":"Other"},{"subitem_subject":"ERG","subitem_subject_scheme":"Other"},{"subitem_subject":"視細胞変性","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜色素変性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"視細胞変性疾患における網膜電図（ERG）の新しい概念確立に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"視細胞変性疾患における網膜電図（ERG）の新しい概念確立に関する研究","subitem_title_language":"ja"},{"subitem_title":"New concept of electroretinography in photoreceptor degenerative diseases","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670486782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-19"},"publish_date":"2022-01-19","publish_status":"0","recid":"14510","relation_version_is_last":true,"title":["視細胞変性疾患における網膜電図（ERG）の新しい概念確立に関する研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T05:32:48.918956+00:00"}