{"created":"2023-06-19T11:44:33.864081+00:00","id":14527,"links":{},"metadata":{"_buckets":{"deposit":"ad51f81d-3410-4b7e-b3cf-66fbf12cc17c"},"_deposit":{"created_by":15,"id":"14527","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14527"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014527","sets":["631:636:1692684799396"]},"author_link":["47656","47657"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-13","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Long-noncoding RNA(IncRNA)は薬の薬効や副作用を規定する薬物トランスポータや薬物代謝酵素の発現調節への関与が指摘されている。本研究では、ヒト小腸上皮細胞において酸化ストレス暴露によりP-糖タンパク(P-gp)の発現量が上昇することを確認し、IncRNAの一種であるCRNDE(Coloretal neoplasia differentially expressed)がP-gpの発現量を調節することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":" Long-noncoding RNA (IncRNA) should regulate the expression of drug-metabolizing enzymes and drug transporters, which affect the efficacy and adverse effect of drugs. In the present study, we demonstrated that the expression level of P-glycoprotein(P-gp/MDR1) was increased in human colon carcinoma cell line Caco-2 cell by the exposure of oxidative stress. In addition, the present findings suggested that CRNDE (Colorectal neoplasia differentially expressed), which is a type of IncRNA, regulated the expression of MDR1.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K08411","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池村, 健治","creatorNameLang":"ja"},{"creatorName":"イケムラ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikemura, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥田, 真弘","creatorNameLang":"ja"},{"creatorName":"オクダ , マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Okuda, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0061.pdf","filesize":[{"value":"221.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0061","url":"https://mie-u.repo.nii.ac.jp/record/14527/files/2021RP0061.pdf"},"version_id":"b86c598a-437d-4a4a-8c05-e8f2eed2dc5a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Long-noncoding RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物トランスポータ","subitem_subject_scheme":"Other"},{"subitem_subject":"P-糖蛋白質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"酸化ストレス応答性lncRNAを介した薬物動態制御タンパク質の発現調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化ストレス応答性lncRNAを介した薬物動態制御タンパク質の発現調節機構の解明","subitem_title_language":"ja"},{"subitem_title":"Analysis on the expression of protein regulating pharmacokinetics via oxidative stress-response IncRNA","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14527","relation_version_is_last":true,"title":["酸化ストレス応答性lncRNAを介した薬物動態制御タンパク質の発現調節機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:00.223072+00:00"}