@techreport{oai:mie-u.repo.nii.ac.jp:00014531,
 author = {市川, 泰崇 and Ichikawa, Yasutaka and 中山, 良平 and Nakayama, Ryohei and 永田, 幹紀 and Nagata, Motonori and 佐久間, 肇 and Sakuma, Hajime and 市原, 隆 and Ichihara, Takashi},
 month = {May},
 note = {肝パーフェージョンCT撮影法の最適化を行い、数理モデル処理によって、門脈血と動脈血のそれぞれの肝血流マップを作成し、さらにCT値変化かた血管内成分と肝実質を分離する手法を開発して、門脈や肝静脈などの肝内血管成分を取り除いた肝実質灌流を反映した肝血流マップを作成する手法を開発した。これにより任意の局所肝領域の門脈血流量及び動脈血流量が計測可能となった。またTc-99m GSA肝受容体 SPECT/CTの定量評価で得られる全肝のトレーサー摂取率が、病理学的な肝線維化の重症度と有意な相関を示し、重度の肝線維化を感度, 特異度ともに約90%の高い精度で検出できることがわかった。, In this study, liver perfusion CT protocol was optimized to achive both high temporal resolution and low radiation dose exposure. With mathematical model, portal and arterial perfusion maps could be created separately. We developed a method to separate the intravascular component from the liver perfusion map based on the change in CT value, and to create a hepatic perfusion map that reflectes the hepatic parenchymal perfusion with the removal of  intravascular components. This method enables portal and arterial blood flow measurements in any region of the liverparenchyma. In addition, this study demonstrated that the uptake ratio of whole liver obtained by quantitative analysis of Tc-99m GSA SPECT/CT was significantly associated with the extent of pathological liver fibrosis. By using the liver uptake ration on Tc-99m GSA SPECT/CT, severe liver fibrosis could be detected with a high sensitivity and specificity of approximately 90%., 2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書, 17K10359},
 title = {肝動脈灌流・門脈灌流と肝細胞機能の統合的診断法の開発と肝切除術前評価への応用},
 year = {2020},
 yomi = {イチカワ, ヤスタカ and ナカヤマ, リョウヘイ and ナガタ, モトノリ and サクマ, ハジメ and イチハラ, タカシ}
}