{"created":"2023-06-19T11:44:34.125793+00:00","id":14533,"links":{},"metadata":{"_buckets":{"deposit":"e5b7daf1-9945-4f5d-b0d4-1030eca8c413"},"_deposit":{"created_by":15,"id":"14533","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14533"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014533","sets":["631:636:1692684799396"]},"author_link":["47700","47701","47702","47703"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"潰瘍性大腸炎患者の直腸粘膜の網羅的DNAメチル化解析を施行した。大腸癌合併潰瘍性大腸炎患者の直腸粘膜と大腸癌非合併潰瘍性大腸炎患者の直腸粘膜を用いて、全ゲノムのメチル化プロファイルを行った。大腸癌合併潰瘍性大腸炎に有意に変化を認める11の部位を同定した(11DMRs)。直腸粘膜における11DMRsを用いた大腸癌合併潰瘍性大腸炎患者診断能は極めて高かった。\n網羅的DNAメチル化解析により11DMRsを選択できた。これらのマーカーは大腸癌合併する潰瘍性大腸炎患者を選択できることが示唆され、今後の前向試験を検討している。","subitem_description_type":"Abstract"},{"subitem_description":" We conducted comprehensive methylation array to identify novel DNA methylation markers for predicting the risk of neoplasia in UC patients. We collected 23 rectal samples from UC patients with CRC and 24 rectal samples from UC patients in cohort1. We also collected 8 rectal samples from UC patients with CRC and 24 rectal samples from UC patients without CRC in cohort 2.\nWe identified 486 differentially methylated regions (DMRs) with absolute delta beta-value > 0.1 in rectal mucosal tissues of UC patients with CAC compared with that without neoplasia. Next, pathway enrichment analysis was performed to select coordinately methylated DMRs, and 180 DMRs were extracted. Finally, optimal 11 DMRs were selected by the Elastic Net classification algorithm. In the ROC analysis for cohort 1, the AUC was 0.96. For cohort 2, the AUC was 0.81. We identified 11 DMRs for identifying UC patients with high risk of developing CAC.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K10628","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"アラキ, トシミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0067.pdf","filesize":[{"value":"379.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0067","url":"https://mie-u.repo.nii.ac.jp/record/14533/files/2021RP0067.pdf"},"version_id":"4c181e67-a5fb-4253-91b0-93ea67cd864e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAメチル化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌合併潰瘍性大腸炎患者の早期診断を目指した新たなスクリーニング方法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌合併潰瘍性大腸炎患者の早期診断を目指した新たなスクリーニング方法の確立","subitem_title_language":"ja"},{"subitem_title":"Establishment of the method to identify the ulcerative colitis patients with high risk of colorectal cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14533","relation_version_is_last":true,"title":["大腸癌合併潰瘍性大腸炎患者の早期診断を目指した新たなスクリーニング方法の確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:15.416529+00:00"}