{"created":"2023-06-19T11:44:34.255673+00:00","id":14536,"links":{},"metadata":{"_buckets":{"deposit":"2f113037-13b9-43d3-9ee8-3ace8394e9b1"},"_deposit":{"created_by":15,"id":"14536","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14536"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014536","sets":["631:636:1692684799396"]},"author_link":["47739"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-27","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腸内細菌が生体の免疫機能を調節して各種炎症性疾患の発症に関連することに着目し、敗血症急性期のSIRSから晩期のImmunoparalysisへ移行する際の腸内細菌の変動を解析し、腸内細菌を利用して低下した免疫機能を賦活できるか盲腸結紮穿刺（CLP）敗血症モデルマウスでの腸内細菌の変動解析を用いて解析を行った。さらにICUに入室した敗血症と敗血症以外のSIRSを来す患者の患者重症度スコア（SOFA・APACHEII）と血中のPD-L1、PD-L2との関係を解析した。","subitem_description_type":"Abstract"},{"subitem_description":"We analyzed the changes in intestinal bacteria during the transition from SIRS in the acute phase of sepsis to immunoparalysis in the late phase, as we focus on the fact that intestinal bacteria regulate the immune function of the body and are involved in the development of various inflammatory diseases. To identify the hypothesis that the internal bacteria activates the decreased immune function, we study the intestinal bacteria in a cecal ligation and puncture (CLP) sepsis model mouse. Furthermore, we investigated the relationship between the patient severity score (SOFA / APACHEII) and soluble PD-L1/L2 in critical patients with sepsis or without sepsis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2019年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K20387","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 亜紗実","creatorNameLang":"ja"},{"creatorName":"イトウ, アサミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Asami","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0070.pdf","filesize":[{"value":"174.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0070","url":"https://mie-u.repo.nii.ac.jp/record/14536/files/2021RP0070.pdf"},"version_id":"4c4cca41-f578-45de-95ca-458851fd4bc3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫麻痺","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌叢","subitem_subject_scheme":"Other"},{"subitem_subject":"PD-L1/L2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腸内細菌を基盤にしたimmunoparalysisの病態形成と治療法に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腸内細菌を基盤にしたimmunoparalysisの病態形成と治療法に関する検討","subitem_title_language":"ja"},{"subitem_title":"Study on pathogenesis and treatment for immunoparalysis based on enterobacteria","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14536","relation_version_is_last":true,"title":["腸内細菌を基盤にしたimmunoparalysisの病態形成と治療法に関する検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:19.867259+00:00"}