{"created":"2023-06-19T11:44:34.469440+00:00","id":14541,"links":{},"metadata":{"_buckets":{"deposit":"25b7d08e-e680-407f-8c99-066a4443bd24"},"_deposit":{"created_by":15,"id":"14541","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14541"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014541","sets":["631:636:1692684799396"]},"author_link":["47754"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"去勢抵抗性前立腺癌（CRPC）において、血中循環前立腺癌細胞にアンドロゲン受容体スプライシングバリアント(ARVs)の発現が見られた場合、新規AR阻害薬も無効である。癌関連線維芽細胞(CAFs)を中心とする癌微小環境が、前立腺癌細胞の細胞内シグナルを活性化し、治療抵抗性ARVsの発現を誘導するという仮説を立て、前立腺癌細胞株におけるARVs発現に対する前立腺線維芽細胞の役割を検討した。その結果、一部の前立腺線維芽細胞が前立腺癌細胞におけるARVs発現を上昇させることを明らかにした。前立腺癌関連線維芽細胞由来パラクライン刺激による前立腺癌細胞のARVs発現修飾作用の可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Expression of androgen receptor (AR) splice variant (AR-V) has been identified as the mechanism associated with the development of castration-resistant prostate cancer (PCa). However, the mechanisms mediating increased expression of aberrant AR-Vs in PCa are still largely unknown.The purpose of this study was to identify if prostate fibroblasts in tumor stroma induces the expression of aberrant AR-Vs in PCa.We investigated the mRNA expression of AR, PSA, AR-V1, AR-V567es, AR-V7, and its target genes by co-cultured with three fibroblasts lines (PrSC, pcPrFs-M28, and pcPrFs-M31).mRNA expression of AR, AR-V1, and AR-V7 in LNCaP cells were increased by co-culture with pcPrFs-M28 but not with PrSC and pcPrFs-M31.Primary cultured prostate fibroblasts from prostate cancer specimens increased expression of aberrant AR-V1 and AR-V7 in PCa cells. Prostate fibroblasts in tumor stroma may be a target for the treatment preventing the expression of aberrant AR-Vs in PCa.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2019年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K16690","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 豪","creatorNameLang":"ja"},{"creatorName":"ササキ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0075.pdf","filesize":[{"value":"82.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0075","url":"https://mie-u.repo.nii.ac.jp/record/14541/files/2021RP0075.pdf"},"version_id":"2a07aafd-2020-406b-87ad-8570aa0becd7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"癌関連線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"スプライシングバリアント","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌間質と去勢抵抗性前立腺癌；スプライシングバリアント制御による新規治療戦略の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌間質と去勢抵抗性前立腺癌；スプライシングバリアント制御による新規治療戦略の開発","subitem_title_language":"ja"},{"subitem_title":"Effects of prostate cancer associated fibroblasts in the expression of aberrant andorgen splicing variants in prostate cancer cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14541","relation_version_is_last":true,"title":["癌間質と去勢抵抗性前立腺癌；スプライシングバリアント制御による新規治療戦略の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:34.211440+00:00"}