{"created":"2023-06-19T11:44:34.511617+00:00","id":14542,"links":{},"metadata":{"_buckets":{"deposit":"7fe06c68-285a-487c-b2f7-64593243b2b9"},"_deposit":{"created_by":15,"id":"14542","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14542"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014542","sets":["631:636:1692684799396"]},"author_link":["47757","47758","47759"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪肝（NAFLD）患者では疫学的に動脈硬化を有する例が多いことが示されているが、脂肪化肝細胞が動脈硬化形成にどのような役割を果たすかは明らかになっていない。今回の研究では脂肪化肝細胞より分泌された細胞外小胞（EV）が血管平滑筋細胞の炎症、アポトーシス、遊走関連遺伝子の発現を増強させることと平滑筋細胞の遊走能を増強させることを示した。これにより脂肪化肝細胞がEVを介して動脈硬化を発症させる機序が示された。","subitem_description_type":"Abstract"},{"subitem_description":"Several epidemiologic studies have shown NAFLD has close relation to atherosclerosis, however, whether steatotic liver cells can directly induce atherosclerosis is not clear yet. In this study, we showed extracellular vesicles (EV) derived from steatotic liver cells enhanced the gene expressions related inflammation, apoptosis and cell motility of arterial smooth muscle cells, and also enhanced cell migration of these cells. These data indicate steatotic liver cells play an important role in the generation of atherosclerosis by releasing EV.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K09355","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉本, 和史","creatorNameLang":"ja"},{"creatorName":"スギモト, カズシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Kazushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"江口, 暁子","creatorNameLang":"ja"},{"creatorName":"エグチ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白木, 克哉","creatorNameLang":"ja"},{"creatorName":"シラキ, カツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiraki, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0076.pdf","filesize":[{"value":"347.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0076","url":"https://mie-u.repo.nii.ac.jp/record/14542/files/2021RP0076.pdf"},"version_id":"f6c6e62a-00dd-4824-81c3-dfddaf08dd3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪肝","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪肝における肝由来低エントロピー小胞による動脈硬化発症のメカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪肝における肝由来低エントロピー小胞による動脈硬化発症のメカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"The role of low entropy extracellular vesicles derived from steatotic liver cells on the generation of atherosclerosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14542","relation_version_is_last":true,"title":["脂肪肝における肝由来低エントロピー小胞による動脈硬化発症のメカニズムの解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:34.610136+00:00"}