{"created":"2023-06-19T11:44:34.597511+00:00","id":14544,"links":{},"metadata":{"_buckets":{"deposit":"978b6d1e-36eb-468c-8f08-d3b7b47e9dc3"},"_deposit":{"created_by":15,"id":"14544","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14544"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014544","sets":["631:636:1692684799396"]},"author_link":["47769","47770"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"骨軟部腫瘍における腫瘍内pHが6.9以下であることから、ポリエチレングリコール を付加して循環血液中での長期滞留性を有し、直径100nm以下にして腫瘍内の異常血管から漏出して腫瘍に蓄積し、pH6.7前後の弱酸性で反応して内容物を放出させる、pH反応性リポソームの作成に成功した。骨肉腫細胞移植マウスに対し腫瘍集積性を示したが、メソトレキセートを封入したリポソームの投与ではマウスが死亡したため、一定の毒性があることがわかった。細胞レベルでは、低pH環境では細胞周囲に抗がん剤を放出し、低pHではない場合はがん細胞にリポソームごと取り込まれ、細胞内に抗がん剤を放出する、２つのデリバリ機能を有していた。","subitem_description_type":"Abstract"},{"subitem_description":"pH in bone and soft tissue tumor is below 6.9. We designed liposome based on next three concept, 1) long stability and escape from immune and reticuloendothelial system by adding polyethyleneglycol, 2)infiltration from abnormal vascular and accumulation in tumor tissue by under 100nm of diameter, 3) release drugs below pH6.7. We successfully produced new concept liposome and this liposome accumulated tumor tissue using mouse xenograft model. However, by intravascular injection of methotrexate encapsulated liposome induced mouse death. From this results, this liposome had a toxicity by vascular injection. In cell experiment, this liposome deliver and release drugs by activation of low pH and deliver drugs inside of cells by endocytosis irrelatively pH. This liposome has 2 delivery system based on pH level.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2019年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K10856","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"淺沼, 邦洋","creatorNameLang":"ja"},{"creatorName":"アサヌマ, クニヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Asanuma, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉村, 哲郎","creatorNameLang":"ja"},{"creatorName":"ヨシムラ, テツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimura, Tetsuro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"2021RP0078.pdf","filesize":[{"value":"431.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2021RP0078","url":"https://mie-u.repo.nii.ac.jp/record/14544/files/2021RP0078.pdf"},"version_id":"ddd1181f-f705-49f4-88db-9818d6ae9e48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sarcoma","subitem_subject_scheme":"Other"},{"subitem_subject":"pH","subitem_subject_scheme":"Other"},{"subitem_subject":"acidity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新たなコンセプトに基づいたph反応性リポソームによる悪性骨軟部腫瘍への治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新たなコンセプトに基づいたph反応性リポソームによる悪性骨軟部腫瘍への治療戦略","subitem_title_language":"ja"},{"subitem_title":"New concept for bone and soft tissue sarcoma treatment by low-pH sensitive liposome","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684799396"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"14544","relation_version_is_last":true,"title":["新たなコンセプトに基づいたph反応性リポソームによる悪性骨軟部腫瘍への治療戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T02:12:39.678046+00:00"}