{"created":"2023-06-19T11:44:49.666192+00:00","id":14953,"links":{},"metadata":{"_buckets":{"deposit":"64853951-cd41-44f2-9634-f0e58168524d"},"_deposit":{"created_by":16,"id":"14953","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"14953"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00014953","sets":["334:608:618:1308"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deregulation of the immune system in sepsis plays the central role in the pathogenesis of multiple organ failure including septic lung injury. Group 2 innate lymphoid cells (ILC2s) have emerged as a new player in regulating immune homeostasis in the lung; however, the role of ILC2s in lung injury in sepsis remains poorly understood. Here, we investigated temporal changes in stimulatory and inhibitory receptor expression and intracellular type 2 cytokine expression of ILC2s in the lung using a cecal ligation and puncture mouse sepsis model. We found that IL-13 production by ILC2s, which were predominately composed of the resident natural ILC2 subset rather than the migratory inflammatory ILC2 subset, was reduced in the lungs of sepsis mice on day 1 and gradually restored through day 7. Although the expression levels of ST2 and inducible T-cell costimulatory (stimulatory receptors) were high, IL-13 production by ILC2s was reduced while showing high programmed cell death 1 (PD-1) (inhibitory receptor) expression. Furthermore, using IL-33 knockout mice, we have shown that IL-33 regulates the capacity of ILC2s to produce IL-13, possibly through the modulation of ST2 and PD-1 expression and signaling in the septic lung. To the best of our knowledge, this is the first report showing differential costimulatory/inhibitory receptor expression on ILC2s in a septic lung in the context of an IL-33/IL-13 pathway-mediated type 2 immune response in the progression and resolution of inflammation. Our present findings contribute to a better understanding of the underlying immunological mechanism of ILC2s and may fill the critical knowledge gap regarding immune homeostasis in the lung that hampers the development of new therapeutic strategies for sepsis-induced acute lung injury.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan","subitem_description_type":"Other"},{"subitem_description":"22p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2103号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/SHK.0000000000001647","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"SHOCK, vol.55, No.3, pp.357-370に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akama, Yuichi","creatorNameLang":"en"},{"creatorName":"アカマ, ユウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"赤間, 悠—","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-20"}],"displaytype":"detail","filename":"2021DM0302.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2021DM0302","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/14953/files/2021DM0302.pdf"},"version_id":"7ecb074a-ad32-4ca9-a444-2a108e98b522"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acute lung injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"group 2 innate lymphoid cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-13","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"KLRG1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"natural and inflammatory ILC2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PD-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ST2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"SEPSIS INDUCES DEREGULATION OF IL-13 PRODUCTION AND PD-1 EXPRESSION IN LUNG GROUP 2 INNATE LYMPHOID CELLS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SEPSIS INDUCES DEREGULATION OF IL-13 PRODUCTION AND PD-1 EXPRESSION IN LUNG GROUP 2 INNATE LYMPHOID CELLS","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1308"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-20"},"publish_date":"2022-07-20","publish_status":"0","recid":"14953","relation_version_is_last":true,"title":["SEPSIS INDUCES DEREGULATION OF IL-13 PRODUCTION AND PD-1 EXPRESSION IN LUNG GROUP 2 INNATE LYMPHOID CELLS"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-17T02:03:55.910496+00:00"}