{"created":"2023-06-19T11:45:03.063970+00:00","id":15256,"links":{},"metadata":{"_buckets":{"deposit":"dc98c3fe-c08d-4571-9e59-5ac175d39d8c"},"_deposit":{"created_by":15,"id":"15256","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15256"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015256","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"感染症防御の最前線である粘膜組織へのエフェクター/メモリー・リンパ球ホーミングが過少であれば生体防御能が低下する、一方過剰であれば組織障害につながる可能性がある。本研究ではリンパ球自身が分泌するエキソソームが先回りして遠隔臓器に作用し、リンパ球ホーミングを制御する新規メカニズムを見出した。粘膜指向性リンパ球が分泌するエキソソームはホーミング受容体インテグリンa4b7を高発現し、マイクロRNAを介したエピジェネティックな様式で、遠隔臓器の血管内皮に作用しMAdCAM-1を含むインテグリンリガンド発現抑制により、ホーミングを負に制御する重要なブレーキとして機能することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The homing of effector/memory lymphocytes to mucosal tissues, which is the frontline of infectious disease defense, can lead to a decrease in the body's defensive capacity if it is insufficient, while excessive homing can lead to tissue damage that could be associated with inflammatory bowel diseases. In this study, we have found a novel mechanism by which exosomes secreted by lymphocytes themselves regulate lymphocyte homing by preemptively acting on distant organs such as intestinal mucosal tissues. The exosomes secreted by mucosal-directed lymphocytes highly express the homing receptor integrin a4b7 and act on the vascular endothelium of distant organs in a microRNA-mediated epigenetic manner to negatively regulate homing by suppressing integrin ligand expression, including MAdCAM-1. The results showed that MAdCAM-1 acts as an important brake to negatively regulate homing by suppressing the expression of integrin ligands including MAdCAM-1.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18H02622","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島岡, 要","creatorNameLang":"ja"},{"creatorName":"シマオカ, モトム","creatorNameLang":"ja-Kana"},{"creatorName":"Shimaoka, Motomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川本, 英嗣","creatorNameLang":"ja"},{"creatorName":"カワモト, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawamoto, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"朴, 恩正","creatorNameLang":"ja"},{"creatorName":"パク, ウンゾン","creatorNameLang":"ja-Kana"},{"creatorName":"Park, Eun Jeong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高娃, 阿栄","creatorNameLang":"ja"},{"creatorName":"ゴワ, アロン","creatorNameLang":"ja-Kana"},{"creatorName":"Arong, Gaowa","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0016.pdf","filesize":[{"value":"180.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0016","url":"https://mie-u.repo.nii.ac.jp/record/15256/files/2022RP0016.pdf"},"version_id":"afc88517-59d6-47d2-98df-b5587b6c843a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"エキソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外小胞","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞接着","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"エキソソームによる腸管特異的リンパ球ホーミングの制御機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エキソソームによる腸管特異的リンパ球ホーミングの制御機序の解明","subitem_title_language":"ja"},{"subitem_title":"Exosomal regulation of leukocyte trafficking","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15256","relation_version_is_last":true,"title":["エキソソームによる腸管特異的リンパ球ホーミングの制御機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:01:57.355578+00:00"}