{"created":"2023-06-19T11:45:03.514345+00:00","id":15266,"links":{},"metadata":{"_buckets":{"deposit":"13aa023e-df60-4b66-8d92-2ef9dc046169"},"_deposit":{"created_by":15,"id":"15266","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15266"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015266","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dahl食塩感受性高血圧ラットを低食塩群(n=10)、高食塩群(n=10)、高食塩＋ SGLT2阻害薬 (ipragliflozin）群（n=10）、高食塩＋ARB(losartan)群(n=10)、高食塩＋SGLT2阻害薬＋ARB(n=10)群に振り分けた。併用投与群でのみ食塩感受性が改善した。併用投与群では単独治療に比べ腎硬化スコアの有意な改善を示し、心筋肥大ならびに線維化も改善所見が得られた。AT1R, NHE3およびNKCC2の蛋白発現がSGLT2阻害薬単独投与では低下しない一方で、併用療法では両者とも有意に抑制され、AT1R発現抑制作用に関してはARB単独投与よりもさらに優れていた。","subitem_description_type":"Abstract"},{"subitem_description":" Dahl salt-sensitive (DSS) hypertensive rats were treated orally for 8-weekswith normal salt diet (0.3% NaCl), high salt diet (8% NaCl), high salt diet with SGLT2 inhibitor(ipragliflozin 0.04%), high salt diet with ARB (losartan 0.05%), or high salt diet with combination treatment. Only the combination treatment lower blood pressure and improved salt-sensitivity. The combination treatment significantly ameliorated glomerulosclerosis, and reduced cardiomyocyte hypertrophy and perivascular fibrosis. Angiotensin II type 1 receptor (AT1R) protein expression level in the kidney was remarkably suppressed in the combination treatment group compared to the other high salt diet groups. The protein expression level of Na+/H+ exchanger isoform 3 and Na+-K+-Cl- cotransporter 2 were significantly decreased with losartan alone and combination with ipragliflozin.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K08101","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土肥, 薫","creatorNameLang":"ja"},{"creatorName":"ドヒ, カオル","creatorNameLang":"ja-Kana"},{"creatorName":"DOHI, KAORU","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊藤, 正明","creatorNameLang":"ja"},{"creatorName":"イトウ, マサアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡本, 隆二","creatorNameLang":"ja"},{"creatorName":"オカモト, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Okamoto, Ryuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"片山, 鑑","creatorNameLang":"ja"},{"creatorName":"カタヤマ, カン","creatorNameLang":"ja-Kana"},{"creatorName":"Katayama, Kan","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0027.pdf","filesize":[{"value":"726.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0027","url":"https://mie-u.repo.nii.ac.jp/record/15266/files/2022RP0027.pdf"},"version_id":"5156edb9-f18e-40e1-8ba0-e6786cc89cf9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"循環器","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討","subitem_title_language":"ja"},{"subitem_title":"The effect of sodium-glucose co-transporter 2 inhibition on heart failure prevention in Dahl salt-sensitive rats.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15266","relation_version_is_last":true,"title":["食塩感受性高血圧モデルにおけるSGLT2阻害の心不全進展抑制効果の検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:02:20.755729+00:00"}