{"created":"2023-06-19T11:45:03.650746+00:00","id":15269,"links":{},"metadata":{"_buckets":{"deposit":"a6079b69-7190-4fca-bb5b-38ee21340ea4"},"_deposit":{"created_by":15,"id":"15269","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15269"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015269","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-31","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A-to-I RNA editingが高頻度に発生する遺伝子として報告されるAZIN1を、今回胃癌組織でそのRNA editing ratioを定量し、臨床病理学的特徴、生存再発予後に関して検証した。結果として胃癌組織においてはAZIN1 RNA editing ratioは有意に高値であり(p<0.001)、AZIN1 hyper-editing群は生存予後不良であり、多変量解析ではAZIN1 hyper-editingは生存予後不良、再発、同時性リンパ節転移に関する独立したリスク因子として抽出された。","subitem_description_type":"Abstract"},{"subitem_description":" We evaluated AZIN1 RNA editing levels in GC tissues using a RNA editing site-specific quantitative polymerase chain reaction assays. We also analyzed the clinical significance of these results as disease biomarkers in GC patients. As a result, AZIN1 RNA editing levels were significantly elevated in GC tissues. Furthermore, hyper-edited AZIN1 emerged as an independent prognostic factor for OS and DFS in GC patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K08566","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"沖上, 正人","creatorNameLang":"ja"},{"creatorName":"オキガミ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Okigami, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"オクガワ, ヨシナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安田, 裕美","creatorNameLang":"ja"},{"creatorName":"ヤスダ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Hiromi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉山, 繁幸","creatorNameLang":"ja"},{"creatorName":"ヨシヤマ, シゲユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshiyama, Shigeyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大井, 正貴","creatorNameLang":"ja"},{"creatorName":"オオイ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohi, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0030.pdf","filesize":[{"value":"284.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0030","url":"https://mie-u.repo.nii.ac.jp/record/15269/files/2022RP0030.pdf"},"version_id":"2dd8b7cb-26ff-42c6-938f-7838478352cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腹膜播種","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA修飾","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌腹膜播種進展におけるRNA後天的修飾の意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹膜播種進展におけるRNA後天的修飾の意義","subitem_title_language":"ja"},{"subitem_title":"Significance of RNA editing for development of peritoneal metastasis of gastric cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15269","relation_version_is_last":true,"title":["胃癌腹膜播種進展におけるRNA後天的修飾の意義"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:02:26.558219+00:00"}