{"created":"2023-06-19T11:45:03.698862+00:00","id":15270,"links":{},"metadata":{"_buckets":{"deposit":"b860de17-4ecf-4744-b959-231782511e48"},"_deposit":{"created_by":15,"id":"15270","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15270"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015270","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-08","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"あらたなエピゲノムとしてDNA・RNAメチル化の癌化における機序が、近年相次いで報告されてきている。今回、RNAメチル化解析は、その品質不良により安定した解析結果が得られなかったものの、DNAメチル化に関しては、DNAメチル化網羅的解析を行い、その結果から、孤発性大腸癌ならびに潰瘍性大腸炎関連大腸癌特異的に高メチル化を呈するCpGサイトを同定した。また同部位のメチル化を、非癌部直腸粘膜組織検体を用いて定量を行うことで、癌合併潰瘍性大腸炎症例を診断できる可能性を明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we conducted comprehensive methylation analysis using surgical specimens from sporadic colorectal cancer or ulcerative colitis-associated CRC, and successfully identified cancer-specific hypermethylated CpG site. Furthermore, we validated this CpG site using pyrosequencing, and showed that quantification of methylation levels using non-neoplastic rectal mucosa could identify high-risk UC patients for CRC.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K08591","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"オクガワ, ヨシナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤川, 裕之","creatorNameLang":"ja"},{"creatorName":"フジカワ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujikawa, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"アラキ, トシミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0031.pdf","filesize":[{"value":"563.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0031","url":"https://mie-u.repo.nii.ac.jp/record/15270/files/2022RP0031.pdf"},"version_id":"a2c64da3-5282-47c7-a50d-8aaae2b9b20f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"メチル化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"潰瘍性大腸炎関連癌におけるRNAメチル化マーカーの臨床的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"潰瘍性大腸炎関連癌におけるRNAメチル化マーカーの臨床的意義","subitem_title_language":"ja"},{"subitem_title":"Clinical burden of RNA methylation as a diagnostic and predictive marker for colitis-associated cancer.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15270","relation_version_is_last":true,"title":["潰瘍性大腸炎関連癌におけるRNAメチル化マーカーの臨床的意義"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:02:30.803386+00:00"}