{"created":"2023-06-19T11:45:04.093714+00:00","id":15279,"links":{},"metadata":{"_buckets":{"deposit":"55bcad1b-81aa-45e5-b01a-d4f4c16a003d"},"_deposit":{"created_by":15,"id":"15279","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15279"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015279","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"β細胞の死は糖尿病の進行の原因と考えられているが、それを抑制する有用な治療法は未だ確立されていない。トロンボモジュリンは抗凝固因子として知られるが、近年、細胞保護作用を有することが注目されている。我々は糖尿病マウスにおいて、トロンボモジュリンがβ細胞を保護し、インスリン分泌を改善することにより、血糖値の上昇を抑制することを証明した。トロンボモジュリンがβ細胞保護効果を持つ新しい糖尿病治療薬として有用である可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Pancreatic β-cell dysfunction is involved in the progression of diabetes. Thrombomodulin is a glycoprotein on the surface of endothelial cells which has inhibitory effect on cell apoptosis. We evaluated the effect of thrombomodulin on β-cell apoptosis and glucose tolerance in diabetic mice. Thrombomodulin attenuated hyperglycemia, ameliorated insulin secretion, and reduced β cell apoptosis. These results indicate that thrombomodulin has antidiabetic effect by suppressing β-cell apoptosis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2020年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K17960","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安間, 太郎","creatorNameLang":"ja"},{"creatorName":"ヤスマ, タロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuma, Taro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0040.pdf","filesize":[{"value":"243.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0040","url":"https://mie-u.repo.nii.ac.jp/record/15279/files/2022RP0040.pdf"},"version_id":"50e104b2-5e48-4ba5-8624-87129c7d3fce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"β細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"トロンボモジュリン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"β細胞保護を目指した新規糖尿病治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β細胞保護を目指した新規糖尿病治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of diabetes treatment method aiming at beta cell protection","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15279","relation_version_is_last":true,"title":["β細胞保護を目指した新規糖尿病治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:02:50.488236+00:00"}