{"created":"2023-06-19T11:45:04.225939+00:00","id":15282,"links":{},"metadata":{"_buckets":{"deposit":"5a5a8593-9a8d-4b1a-9f33-ac2a5ba5ebfa"},"_deposit":{"created_by":15,"id":"15282","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15282"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015282","sets":["334:627:1692670514969"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病の発症には多くの要因が関係すると考えられているが、近年脂質類のアルツハイマー病への関与を示す報告が多数なされている。脂質は、加熱などにより酸化され過酸化脂質を生じ、この過酸化脂質がさらに生体に酸化ストレスをもたらすことがよく知られている。本研究では、過酸化脂質などにより酸化ストレスを暴露したサルを用いて、細胞死誘導と酸化損傷タンパク質の変動について明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":" Alzheimer's disease is the most common type of dementia and progressive neurodegenerative disease. The recent findings suggest that lipid peroxidation plays an important role in the pathogenesis of Alzheimer's disease. It is well known that lipids are oxidized by heating to produce lipid peroxides, which further cause oxidative stress in the body. In the present study, we investigated the induction of cell death and changes in oxidative damage proteins in monkeys exposed to oxidative stress.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(挑戦的研究(萌芽))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K19673","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"及川, 伸二","creatorNameLang":"ja"},{"creatorName":"オイカワ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"OIKAWA, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山嶋, 哲盛","creatorNameLang":"ja"},{"creatorName":"ヤマシマ, テツモリ","creatorNameLang":"ja-Kana"},{"creatorName":"YAMASHIMA, Tetsumori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小林, 果","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ハタス","creatorNameLang":"ja-Kana"},{"creatorName":"KOBAYASHI, Hatasu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"2022RP0043.pdf","filesize":[{"value":"247.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0043","url":"https://mie-u.repo.nii.ac.jp/record/15282/files/2022RP0043.pdf"},"version_id":"08d674b1-0661-4c6d-ac1c-6defdb0656f7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アルツハイマー病","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオミクス解析","subitem_subject_scheme":"Other"},{"subitem_subject":"過酸化脂質","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"過酸化脂質によるアルツハイマー病発症機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"過酸化脂質によるアルツハイマー病発症機構の解明","subitem_title_language":"ja"},{"subitem_title":"A possible mechanism of Alzheimer's disease caused by lipid peroxidation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670514969"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"15282","relation_version_is_last":true,"title":["過酸化脂質によるアルツハイマー病発症機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:02:59.409817+00:00"}