{"created":"2023-06-19T11:45:04.444988+00:00","id":15287,"links":{},"metadata":{"_buckets":{"deposit":"95e1fffc-099c-4284-a85c-797036d6641e"},"_deposit":{"created_by":15,"id":"15287","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15287"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015287","sets":["631:636:1692684824467"]},"author_link":["50526","50527","50528"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ゲノム編集技術による遺伝子改変ラットを用いて、PAHの肺血管病変における内膜平滑筋細胞の由来する細胞を決定し 、CCR2がPAHの内膜病変形成に必須であるかを生体内で解明した。(A)CCR2 knock-outラットにおけるPAHによる肺血管病変への影響:心エコー、心臓カテーテル検査により血行動態を評価した。knock-outラットで、血行動態と組織病変の改善を認めた。 (B)Myh11-Cre ラットを用いたPAHモデルでの分化型平滑筋細胞のFate mapping解析:現在、ゲノム編集技術を用いて、Mhy11-Cre-ERT2 knock-inラットの作成に成功した。","subitem_description_type":"Abstract"},{"subitem_description":" Using genome-edited rats, we determined the origin of intimal smooth muscle cells in pulmonary vascular lesions of PAH and elucidated whether CCR2 is essential for the formation of intimal lesions in PAH in vivo. (A) Effect of PAH on pulmonary vascular lesions in CCR2knock-out rats: Hemodynamics was evaluated by echocardiography and cardiac catheterization, and hemodynamic and tissue lesions were improved in knock-out rats. (B) Fate mapping analysis of differentiated smooth muscle cells in a PAH model using Myh11-Cre rats: We have now succeeded in generating Myh11-Cre-ERT2 knock-in rats using genome editing technology.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K07841","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三谷, 義英","creatorNameLang":"ja"},{"creatorName":"ミタニ, ヨシヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Mitani, Yoshihide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"丸山, 一男","creatorNameLang":"ja"},{"creatorName":"マルヤマ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruyama, kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤田, 博文","creatorNameLang":"ja"},{"creatorName":"サワダ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sawada, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-28"}],"displaytype":"detail","filename":"2022RP0048.pdf","filesize":[{"value":"188.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0048","url":"https://mie-u.repo.nii.ac.jp/record/15287/files/2022RP0048.pdf"},"version_id":"3106d40d-8dd7-47dc-9055-6b1a292d9c49"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム編集","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR2","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺動脈性肺高血圧の血管病変形成への血管平滑筋と炎症の関与 ：ゲノム編集技術の応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺動脈性肺高血圧の血管病変形成への血管平滑筋と炎症の関与 ：ゲノム編集技術の応用","subitem_title_language":"ja"},{"subitem_title":"Contribution of vascular smooth muscle cells and inflammation to the development of occlusive pulmonary vascular disease","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684824467"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-28"},"publish_date":"2022-11-28","publish_status":"0","recid":"15287","relation_version_is_last":true,"title":["肺動脈性肺高血圧の血管病変形成への血管平滑筋と炎症の関与 ：ゲノム編集技術の応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T04:37:58.819848+00:00"}