{"created":"2023-06-19T11:45:04.750307+00:00","id":15294,"links":{},"metadata":{"_buckets":{"deposit":"ae1ff114-a442-4e76-b7af-990e8f734e39"},"_deposit":{"created_by":15,"id":"15294","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15294"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015294","sets":["631:636:1692684824467"]},"author_link":["50613","50614","50615"],"control_number":"15294","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"血中動態と異なり、眼内のprotein S (PS)は糖尿病(DM) 眼で疾患の重症度に準じて増加していた。とくにDMEにおいて著明に上昇していた。ヒト剖検眼を用いた検討でも、糖尿病網膜でのPS発現が認められた。また、術中採取した嚢胞様腔を染色し、PSが腔内に集積していることが明らかとなった。マウス糖尿病モデルの網膜ではPSの著明な発現は認められなかった。以上から、PSは糖尿病網膜症/糖尿病黄斑浮腫と密接に関与することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"Unlike blood kinetics, ocular protein S (PS) increased in diabetic eyes in accordance with the severity of the disease. In particular, it was markedly elevated in DME. In a study of human autopsy eyes, PS was also observed in diabetic retinas. Staining of intraoperatively collected cyst-like spaces revealed that PS accumulated in the spaces.\nNo significant expression of PS was observed in the retina of the mouse diabetic model.\nThese results indicate that PS is closely related to diabetic retinopathy/diabetic macular edema.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K09402","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉本, 昌彦","creatorNameLang":"ja"},{"creatorName":"スギモト, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gabazza, Esteban","creatorNameLang":"en"},{"creatorName":"ガバザ, エステバン","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 峰生","creatorNameLang":"ja"},{"creatorName":"コンドウ, ミネオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Mineo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-28"}],"displaytype":"detail","filename":"2022RP0055.pdf","filesize":[{"value":"98.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0055","url":"https://mie-u.repo.nii.ac.jp/record/15294/files/2022RP0055.pdf"},"version_id":"211354be-37f7-4915-a60c-d925ea5297c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病網膜症","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病黄斑浮腫","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテインS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖尿病網膜症の進行阻止における血液凝固関連因子が果たす新たな機能の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病網膜症の進行阻止における血液凝固関連因子が果たす新たな機能の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of a novel function of blood coagulation-related factors in arresting the progression of diabetic retinopathy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684824467"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-28"},"publish_date":"2022-11-28","publish_status":"0","recid":"15294","relation_version_is_last":true,"title":["糖尿病網膜症の進行阻止における血液凝固関連因子が果たす新たな機能の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-19T23:41:06.944821+00:00"}