{"created":"2023-06-19T11:45:04.838456+00:00","id":15296,"links":{},"metadata":{"_buckets":{"deposit":"e5998709-8841-48a4-9f70-65e623cfdaf9"},"_deposit":{"created_by":15,"id":"15296","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15296"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015296","sets":["631:636:1692684824467"]},"author_link":["50628","50629"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"実験に使用した高転移悪性黒色腫細胞株A375SMのPDEの発現について確認を行った結果、PDE1活性とPDE1C mRNAの発現を確認した。また、PDE5Aの発現はわずかで、以前の悪性黒色腫細胞株MAAのPDE発現の特徴と一致していた。　\nA375SM cellを眼窩静脈叢から移植し肺転移を確認したが、PDE1阻害効果を確認するためのsildenafilの至適濃度についてはさらなる検討が必要である。","subitem_description_type":"Abstract"},{"subitem_description":"As a result of confirming the expression of PDE in the highly metastatic malignant melanoma cell line A375SM used in the experiment, the expression of PDE1 activity and PDE1C mRNA was confirmed. In addition, the expression of PDE5A was slight, consistent with the characteristics of PDE expression of MAA.\nPulmonary metastasis was confirmed by transplanting A375SM cells from the orbital venous plexus, but it was thought that sufficient effects could not be expected by the method of allowing cells to act with a PDE1 inhibitor and then transplanting to mice, so inhibition after transplanting A375SM cells. We decided to perform the experiment by intraperitoneally administering the drug and comparing the lung metastases with the control group. However, further studies are needed on the optimal concentration of sildenafil to confirm the PDE1 inhibitory effect.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K09765","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 香澄","creatorNameLang":"ja"},{"creatorName":"シミズ, カスミ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, Kasumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村田, 琢","creatorNameLang":"ja"},{"creatorName":"ムラタ, タク","creatorNameLang":"ja-Kana"},{"creatorName":"Murata, Taku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50629","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-28"}],"displaytype":"detail","filename":"2022RP0057.pdf","filesize":[{"value":"78.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0057","url":"https://mie-u.repo.nii.ac.jp/record/15296/files/2022RP0057.pdf"},"version_id":"89d8fb4d-6721-4490-82f9-3fee5796b0a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"phosphodiesterase","subitem_subject_scheme":"Other"},{"subitem_subject":"悪性腫瘍","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔悪性黒色腫新治療薬の開発-PDE1阻害剤の臨床応用を目指して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔悪性黒色腫新治療薬の開発-PDE1阻害剤の臨床応用を目指して","subitem_title_language":"ja"},{"subitem_title":"Studies for clinical application of PDE1 inhibitors to the treatment of malignant melanoma","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684824467"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-28"},"publish_date":"2022-11-28","publish_status":"0","recid":"15296","relation_version_is_last":true,"title":["口腔悪性黒色腫新治療薬の開発-PDE1阻害剤の臨床応用を目指して"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T04:38:23.061589+00:00"}