{"created":"2023-06-19T11:45:06.153275+00:00","id":15326,"links":{},"metadata":{"_buckets":{"deposit":"36786a34-eeff-486a-b680-5492cafec18a"},"_deposit":{"created_by":15,"id":"15326","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15326"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015326","sets":["515:756:1692664592836"]},"author_link":["50781","50782","50783"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"糖尿病性腎症は末期腎不全の第１位の原因疾患であり、２型糖尿病患者の生命予後を左右する。糖尿病性腎症を克服するには、発症分子機構の解明と治療標的遺伝子の探索が不可欠である。我々は、ゼブラフィッシュを用いた２型糖尿病性腎症モデルの開発を行い、持続する高血糖状態、漏れ続けるタンパク尿と腎臓糸球体の病変が確認され、世界で初めて糖尿病性腎症モデルゼブラフィッシュの構築が成功した。さらに、RNA-seqによるトランスクリプトーム解析を行った結果、糖尿病性腎症の発症並びに治療に関連する遺伝子群を抽出した。","subitem_description_type":"Abstract"},{"subitem_description":"Diabetic nephropathy is the major causative disorder of end-stage renal disease and affects the prognosis of patients with type 2 diabetes. It is essential to clarify the underlying molecular mechanism of the onset of this disease and identify the therapeutic target genes. This study successfully developed a type 2 diabetic nephropathy model using zebrafish. The characteristics of this model include persistent hyperglycemia, continuously leaking proteinuria, and renal glomerular lesions. To our knowledge, this is the first time to create a diabetic nephropathy model in zebrafish. Furthermore, we performed transcriptome analysis by RNA-seq. As the results, candidate genes related to the onset of diabetic nephropathy and therapeutic target genes were identified.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2020年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K08240","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臧, 黎清","creatorNameLang":"ja"},{"creatorName":"ゾウ, レイシン","creatorNameLang":"ja-Kana"},{"creatorName":"Zang, Liqing","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"島田, 康人","creatorNameLang":"ja"},{"creatorName":"シマダ, ヤスヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Yasuhito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"齋藤, 成","creatorNameLang":"ja"},{"creatorName":"サイトウ, セイ","creatorNameLang":"ja-Kana"},{"creatorName":"Saitoh, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-29"}],"displaytype":"detail","filename":"2022RP0087.pdf","filesize":[{"value":"116.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0087","url":"https://mie-u.repo.nii.ac.jp/record/15326/files/2022RP0087.pdf"},"version_id":"f93cfcaf-d4a0-4200-ac20-76dc1f445acc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病性腎症","subitem_subject_scheme":"Other"},{"subitem_subject":"２型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼブラフィッシュ","subitem_subject_scheme":"Other"},{"subitem_subject":"モデル動物","subitem_subject_scheme":"Other"},{"subitem_subject":"メカニズム解析","subitem_subject_scheme":"Other"},{"subitem_subject":"治療標的遺伝子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"２型糖尿病性腎症モデルゼブラフィッシュの構築および治療標的遺伝子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"２型糖尿病性腎症モデルゼブラフィッシュの構築および治療標的遺伝子の探索","subitem_title_language":"ja"},{"subitem_title":"Development of a zebrafish model for diabetic nephropathy and the identification of the therapeutic target genes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692664592836"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-29"},"publish_date":"2022-11-29","publish_status":"0","recid":"15326","relation_version_is_last":true,"title":["２型糖尿病性腎症モデルゼブラフィッシュの構築および治療標的遺伝子の探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-22T00:12:32.420599+00:00"}