{"created":"2023-06-19T11:45:06.198623+00:00","id":15327,"links":{},"metadata":{"_buckets":{"deposit":"3363ae65-bcb9-4ad1-a807-61a965cf6843"},"_deposit":{"created_by":15,"id":"15327","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15327"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00015327","sets":["515:756:1692664592836"]},"author_link":["50790"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、ゼブラフィッシュおよびマウス脂肪細胞系を用いて、紅藻Palmaria mollis(PM)に含まれる抗肥満成分およびその作用メカニズムを明らかにすることを目的とした。\nPMを様々な溶媒で画分化し、内臓脂肪蓄積をよく抑制する抽出物の同定を行った。その後、さらに10画分の画分調製を行い、その後ゼブラフィッシュを用いて検討、その中で最も効果のあったものに含まれる成分をLC-MSやNMRを用いて同定した。この成分の抗肥満作用メカニズムは、これまで私が報告したPMと同様にppargの発現を調節し脂肪細胞分化に影響を及ぼしていることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we elucidated the anti-obesity components and their mechanisms of action in the red alga Palmaria mollis using zebrafish and mouse adipocyte systems.\nThe PM was fractionated in various solvents to identify extracts that inhibit visceral fat accumulation well. After that, 10 more fractions were prepared and then examined using zebrafish, and the components in the most effective ones were identified using LC-MS and NMR. The mechanism of anti-obesity action of this component was found to be the same as that of PM, which I have reported, regulating pparg expression and affecting adipocyte differentiation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2020年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K20144","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中山, 寛子","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Hiroko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50790","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-29"}],"displaytype":"detail","filename":"2022RP0088.pdf","filesize":[{"value":"89.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2022RP0088","url":"https://mie-u.repo.nii.ac.jp/record/15327/files/2022RP0088.pdf"},"version_id":"386e1300-4f69-47be-90fd-4b6e6c0778c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗肥満作用","subitem_subject_scheme":"Other"},{"subitem_subject":"天然物","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼブラフィッシュ","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"機能性食品","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新たな機能性食品、紅藻Palmaria mollisの内臓脂肪抑制成分の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新たな機能性食品、紅藻Palmaria mollisの内臓脂肪抑制成分の探索","subitem_title_language":"ja"},{"subitem_title":"Exploration study on visceral fat suppressing components in a new functional food, red alga Palmaria mollis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692664592836"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-29"},"publish_date":"2022-11-29","publish_status":"0","recid":"15327","relation_version_is_last":true,"title":["新たな機能性食品、紅藻Palmaria mollisの内臓脂肪抑制成分の探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-22T00:12:32.543371+00:00"}