{"created":"2023-08-31T02:38:32.915515+00:00","id":2000037,"links":{},"metadata":{"_buckets":{"deposit":"f5d090a4-19a1-48bf-89bc-8200fcb8f679"},"_deposit":{"created_by":16,"id":"2000037","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000037"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000037","sets":["334:608:618:1336"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-24","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nAnaphylaxis following influenza vaccination is a rare but serious problem. The underlying immune responses are not well understood. This study elucidated the IgE and IgG antibody responses in healthy children and adolescents following inactivated influenza vaccines (IIVs).\nMethods\nThe efficacy and safety of quadrivalent IIV (QIV) and trivalent IIV (TIV) were compared in healthy subjects aged 0–18 years. Serum IIV-specific IgE, IgG, and IgG4 levels (sIgE, sIgG, and sIgG4) were measured with ImmunoCAP. Hemagglutination inhibition (HI) assay was performed for each influenza virus subtype. Sera from earlier patients who developed anaphylaxis to different IIVs were similarly tested.\nResults\nA total of 393 subjects were enrolled: 96 were 6 months−2 years old, 100 were 3–5 years old, 100 were 6–12 years old, and 97 were 13–18 years old. No anaphylaxis was observed. Generally, QIV and TIV induced similar antibody responses. IIV-sIgE levels rose significantly after vaccination in the 6 months–2 years old and 3–5 years old groups, did not change in the 6–12 years old group, and decreased in the 13–18 years old group. In contrast, the IIV-sIgG4/sIgE ratio increased significantly after vaccination in all age groups. Sensitized subjects had significantly higher HI titers and IIV-sIgG levels in the youngest age group and higher IIV-sIgG4 levels in all age groups compared with the non-sensitized. The IIV-sIgG4/sIgE ratio in five patients with anaphylaxis was significantly lower than in age-matched healthy subjects.\nConclusion\nIIVs induce IgE sensitization in healthy children but also robust IgG4 responses that may protect them from anaphylaxis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Child Health and Development, Mie University Graduate School of Medicine, Tsu, Japan","subitem_description_type":"Other"},{"subitem_description":"19p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2181号"}]},"item_7_full_name_2":{"attribute_name":"著者（ヨミ）","attribute_value_mlt":[{"names":[{"name":"バッファー トント, プリンス","nameLang":"ja"}]}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/irv.13053","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Influenza and Other Respiratory Viruses 2022; 1-10に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Baffour Tonto, Prince","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-24"}],"displaytype":"detail","filename":"2022DM0330.pdf","filesize":[{"value":"1.73MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2022DM0330","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000037/files/2022DM0330.pdf"},"version_id":"568707d1-7ee0-42a6-9b2d-b847f121a3fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anaphylaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"influenza vaccine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"specific IgE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"specific IgG4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"specific IgG4/IgE ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1336"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-31"},"publish_date":"2023-08-31","publish_status":"0","recid":"2000037","relation_version_is_last":true,"title":["High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-17T01:55:12.900107+00:00"}